Increased frequency dependence of specific airway resistance in patients with laryngeal hemiplegia

V. Fasano, L. Raiteri, E. Bucchioni, S. Guerra, G. Cantarella, M. G. Massari, B. M. Cesana, L. Allegra

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The aim of this study was to investigate whether patients with laryngeal hemiplegia (LH) show a frequency-dependent increase in specific airway resistance (sRaw), measured by body plethysmography. In addition to the flow-volume loop, usually considered in the functional evaluation of upper airway obstructions, variations in sRaw at respiratory frequencies of 30±5 (=0.5 Hz), 60±5 (=1 Hz) and 90±5 breaths·min-1 (=1.5 Hz) in 21 never-smoking patients (LH group, mean age±SD 55±12.09 yrs; 17 females) whose unilateral vocalcord paralysis was documented by laryngoscopy and who had no signs or symptoms of other respiratory diseases studied. They were compared to 21 healthy control subjects (C group: 50.1±15.44 yrs; 10 females). The sRaw values at 30±5 breaths·min-1 were similar in the two groups (5.54±1.88 versus 5.68±1.06 cmH2O·s-1; p=NS), but at increasing frequencies (30±5, 60±5 and 90±5 breaths·min-1), they progressively and significantly increased in the LH patients (from 5.54±1.88 to 6.63±1.96 and 8.05±2.6 cmH2O·s-1; p<0.0005), and not significantly in controls (5.68±1.06, 5.85±0.95 and 5.9±1.12 cmH2O·s; p=NS). Linear discriminant analysis using ΔsRaw (sRaw at 1.5 Hz-sRaw at 0.5 Hz) and forced inspiratory flow at 50% of the vital capacity made it possible to correctly classify all of the controls and 19 of the 21 patients. In conclusion, the multiple, rapid and noninvasive plethysmographical testing of frequency-dependent increase in specific airway resistance with the flow-volume loop, allows the sufficiently satisfactory discrimination of laryngeal hemiplegia patients from controls.

Original languageEnglish (US)
Pages (from-to)1003-1008
Number of pages6
JournalEuropean Respiratory Journal
Volume18
Issue number6
DOIs
StatePublished - Dec 1 2001
Externally publishedYes

Keywords

  • Body plethysmography
  • Forced inspiratory flow at 50% of the vital capacity
  • Inspiratory flow
  • Laryngeal hemiplegia
  • Specific airway resistance

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Fasano, V., Raiteri, L., Bucchioni, E., Guerra, S., Cantarella, G., Massari, M. G., Cesana, B. M., & Allegra, L. (2001). Increased frequency dependence of specific airway resistance in patients with laryngeal hemiplegia. European Respiratory Journal, 18(6), 1003-1008. https://doi.org/10.1183/09031936.01.00061501