Increased hepatic density and phospholipidosis due to amiodarone

I. S. Goldman, M. L. Winkler, S. E. Raper, M. E. Barker, E. Keung, H. I. Goldberg, Thomas D Boyer

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Amiodarone is an amphiphilic iodinated compound that is used as a treatment for refractory ventricular arrhythmias. During evaluation for possible pulmonary toxicity, a patient receiving amiodarone was noted to have an increase in the density of his liver as seen on computed tomographic (CT) scanning of the abdomen. Six additional patients who were receiving amiodarone were subsequently evaluated to ascertain the frequency of this finding. The CT density of the liver was increased in all patients. Values obtained varied from 95 to 145 H, with a mean of 117 ± 8.9 (normal, 30-70). The alkaline phosphatase was elevated in four patients, but only one had an elevation of either the alanine or aspartate aminotransferase. Two patients underwent liver biopsies, and both revealed membranous lamellar phospholipid-containing structures within hepatocytes. Animal studies done to recreate these findings revealed that amiodarone accumulated in the liver at concentrations 175-500 times greater than those found in serum. Quantitative measurements of iodine in samples from the same liver showed that the iodine levels were correspondingly elevated. In the treated animals, there was a small but statistically significant increase in the CT density of the liver, whereas the values for untreated animals were unchanged. Treatment with amiodarone leads to an accumulation in the liver of this iodinated compound and hence an increase in the CT density of the liver. This accumulation of the drug in hepatic lysosomes apparently causes a secondary phospholipidosis.

Original languageEnglish (US)
Pages (from-to)541-546
Number of pages6
JournalAmerican Journal of Roentgenology
Volume144
Issue number3
StatePublished - 1985
Externally publishedYes

Fingerprint

Amiodarone
Liver
Iodine
Aspartate Aminotransferases
Lysosomes
Alanine Transaminase
Abdomen
Alkaline Phosphatase
Cardiac Arrhythmias
Hepatocytes
Phospholipids
Biopsy
Lung
Therapeutics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Goldman, I. S., Winkler, M. L., Raper, S. E., Barker, M. E., Keung, E., Goldberg, H. I., & Boyer, T. D. (1985). Increased hepatic density and phospholipidosis due to amiodarone. American Journal of Roentgenology, 144(3), 541-546.

Increased hepatic density and phospholipidosis due to amiodarone. / Goldman, I. S.; Winkler, M. L.; Raper, S. E.; Barker, M. E.; Keung, E.; Goldberg, H. I.; Boyer, Thomas D.

In: American Journal of Roentgenology, Vol. 144, No. 3, 1985, p. 541-546.

Research output: Contribution to journalArticle

Goldman, IS, Winkler, ML, Raper, SE, Barker, ME, Keung, E, Goldberg, HI & Boyer, TD 1985, 'Increased hepatic density and phospholipidosis due to amiodarone', American Journal of Roentgenology, vol. 144, no. 3, pp. 541-546.
Goldman IS, Winkler ML, Raper SE, Barker ME, Keung E, Goldberg HI et al. Increased hepatic density and phospholipidosis due to amiodarone. American Journal of Roentgenology. 1985;144(3):541-546.
Goldman, I. S. ; Winkler, M. L. ; Raper, S. E. ; Barker, M. E. ; Keung, E. ; Goldberg, H. I. ; Boyer, Thomas D. / Increased hepatic density and phospholipidosis due to amiodarone. In: American Journal of Roentgenology. 1985 ; Vol. 144, No. 3. pp. 541-546.
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