Increased local antitumor effects of interleukin 2 liposomes in mice with MCA-106 sarcoma pulmonary metastases

Peter M. Andersen, Emmanuel Katsanis, Arnold S. Leonard, Douglas Schow, Cynthia M. Loeffler, Mitchell B. Goldstein, Augusto C. Ochoa

Research output: Contribution to journalArticle

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Abstract

The effects of liposome formulations of interleukin 2 (IL-2) and local route were studied in C57BL/6 mice with MCA-106 sarcoma pulmonary metastases. IL-2 liposomes made by hydration of powdered dimyristoylphosphatidylcholine with aqueous recombinant IL-2 had 95% of the IL-2 associated with the lipid fraction. When mice with pulmonary micrometastases were treated once daily with free cytokine on days 5, 6, and 7 after tumor inoculation, the intrathoracic route was superior to the i.p. or s.c. routes. When IL-2 liposomes were administered by the local intrathoracic route, significantly better antitumor effects (P < 0.01) were seen compared to empty liposomes or free IL-2 as determined by (a) increased survival and (6) reduced numbers of pulmonary metastases. Minimal toxicity was observed. Results indicate that local route and incorporation of IL-2 in liposomes may enhance therapeutic efficacy and facilitate more practical daily dosing regimens.

Original languageEnglish (US)
Pages (from-to)1853-1856
Number of pages4
JournalCancer Research
Volume50
Issue number6
StatePublished - Mar 15 1990
Externally publishedYes

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Liposomes
Sarcoma
Interleukin-2
Neoplasm Metastasis
Lung
Dimyristoylphosphatidylcholine
Neoplasm Micrometastasis
Inbred C57BL Mouse
Cytokines
Lipids
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Andersen, P. M., Katsanis, E., Leonard, A. S., Schow, D., Loeffler, C. M., Goldstein, M. B., & Ochoa, A. C. (1990). Increased local antitumor effects of interleukin 2 liposomes in mice with MCA-106 sarcoma pulmonary metastases. Cancer Research, 50(6), 1853-1856.

Increased local antitumor effects of interleukin 2 liposomes in mice with MCA-106 sarcoma pulmonary metastases. / Andersen, Peter M.; Katsanis, Emmanuel; Leonard, Arnold S.; Schow, Douglas; Loeffler, Cynthia M.; Goldstein, Mitchell B.; Ochoa, Augusto C.

In: Cancer Research, Vol. 50, No. 6, 15.03.1990, p. 1853-1856.

Research output: Contribution to journalArticle

Andersen, PM, Katsanis, E, Leonard, AS, Schow, D, Loeffler, CM, Goldstein, MB & Ochoa, AC 1990, 'Increased local antitumor effects of interleukin 2 liposomes in mice with MCA-106 sarcoma pulmonary metastases', Cancer Research, vol. 50, no. 6, pp. 1853-1856.
Andersen PM, Katsanis E, Leonard AS, Schow D, Loeffler CM, Goldstein MB et al. Increased local antitumor effects of interleukin 2 liposomes in mice with MCA-106 sarcoma pulmonary metastases. Cancer Research. 1990 Mar 15;50(6):1853-1856.
Andersen, Peter M. ; Katsanis, Emmanuel ; Leonard, Arnold S. ; Schow, Douglas ; Loeffler, Cynthia M. ; Goldstein, Mitchell B. ; Ochoa, Augusto C. / Increased local antitumor effects of interleukin 2 liposomes in mice with MCA-106 sarcoma pulmonary metastases. In: Cancer Research. 1990 ; Vol. 50, No. 6. pp. 1853-1856.
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