Increased Local Antitumor Effects of Interleukin 2 Liposomes in Mice with MCA-106 Sarcoma Pulmonary Metastases

Peter M. Anderson, Emmanuel Katsanis, Arnold S. Leonard, Douglas Schow, Cynthia M. Loeffler, Mitchell B. Goldstein, Augusto C. Ochoa

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

The effects of liposome formulations of interleukin 2 (IL-2) and local route were studied in C57BL/6 mice with MCA-106 sarcoma pulmonary metastases. IL-2 liposomes made by hydration of powdered dimyristoyl-phosphatidylcholine with aqueous recombinant IL-2 had 95% of the IL-2 associated with the lipid fraction. When mice with pulmonary micro-metastases were treated once daily with free cytokine on days 5, 6, and 7 after tumor inoculation, the intrathoracic route was superior to the i.p. or s.c. routes. When IL-2 liposomes were administered by the local intrathoracic route, significantly better antitumor effects (P < 0.01) were seen compared to empty liposomes or free IL-2 as determined by (a) increased survival and (b) reduced numbers of pulmonary metastases. Minimal toxicity was observed. Results indicate that local route and incorporation of IL-2 in liposomes may enhance therapeutic efficacy and facilitate more practical daily dosing regimens.

Original languageEnglish (US)
Pages (from-to)1853-1856
Number of pages4
JournalCancer Research
Volume50
Issue number6
StatePublished - Mar 15 1990
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Increased Local Antitumor Effects of Interleukin 2 Liposomes in Mice with MCA-106 Sarcoma Pulmonary Metastases'. Together they form a unique fingerprint.

  • Cite this

    Anderson, P. M., Katsanis, E., Leonard, A. S., Schow, D., Loeffler, C. M., Goldstein, M. B., & Ochoa, A. C. (1990). Increased Local Antitumor Effects of Interleukin 2 Liposomes in Mice with MCA-106 Sarcoma Pulmonary Metastases. Cancer Research, 50(6), 1853-1856.