Increased oesophageal acid exposure at the beginning of the recumbent period is primarily a recumbent-awake phenomenon

L. Allen, C. H. Poh, A. Gasiorowska, I. Malagon, T. Navarro-Rodriguez, H. Cui, J. Powers, B. Moty, M. R. Willis, N. Ashpole, S. F. Quan, R. Fass

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Background A significant increase in oesophageal acid exposure during early recumbent period has been demonstrated. Aim To determine if acid reflux during the early recumbent period occurs in the recumbent-asleep or recumbent-awake period using a novel integrative actigraphy and pH programme. Method Thirty-nine subjects with heartburn at least three times a week were included. Subjects underwent pH testing concomitantly with actigraphy. Simultaneously recorded actigraphy and pH data were incorporated using a novel integrative technique to determine sleep and awake periods. Characteristics of acid reflux were compared between the recumbent-awake and recumbent-asleep periods. Results Seventeen (44.7%) subjects had acid reflux events during recumbent-awake period as compared to seven (18.4%) in the corresponding recumbent-asleep period (P = 0.046). The mean number of acid reflux events in recumbent-awake period was significantly higher than in the corresponding recumbent-asleep period (8.1 ± 4.4 vs. 3.2 ± 1.5, P < 0.001). In the recumbent-awake period, 38.4% of acid reflux events were associated with GERD-related symptoms as compared with 3.7% of acid reflux events during the corresponding recumbent-asleep period (P = 0.01). Conclusion Increased acid reflux in the early recumbent period occurs primarily during the recumbent-awake and not during the recumbent-asleep period.

Original languageEnglish (US)
Pages (from-to)787-794
Number of pages8
JournalAlimentary Pharmacology and Therapeutics
Volume32
Issue number6
DOIs
StatePublished - Sep 15 2010

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

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    Allen, L., Poh, C. H., Gasiorowska, A., Malagon, I., Navarro-Rodriguez, T., Cui, H., Powers, J., Moty, B., Willis, M. R., Ashpole, N., Quan, S. F., & Fass, R. (2010). Increased oesophageal acid exposure at the beginning of the recumbent period is primarily a recumbent-awake phenomenon. Alimentary Pharmacology and Therapeutics, 32(6), 787-794. https://doi.org/10.1111/j.1365-2036.2010.04403.x