Increased prevalence of third-degree atrioventricular block in patients with type II diabetes mellitus

Mohammad R Movahed, Mehrtash Hashemzadeh, M. Mazen Jamal

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: Diabetes mellitus (DM) is a major risk for cardiovascular disease and mortality. There is some evidence that third-degree atrioventricular (AV) block occurs more commonly in patients with DM. In this study, we evaluated any possible association between DM and third-degree AV block using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes in a very large inpatient database. Method: We used patient treatment files containing discharge diagnoses using ICD-9 codes of inpatient treatment from all Veterans Health Administration hospitals. The cohort was stratified using the ICD-9-CM code for DM (n = 293,124), a control group with hypertension but no DM (n = 552,623), and the ICD-9 code for third-degree AV block (426.0) and smoking (305.1, V15.82). We performed multivariate analysis adjusting for coronary artery disease, congestive heart failure, smoking, and hyperlipidemia. Continuous and binary variables were analyzed using χ2 and Fisher exact tests. Results: Third-degree AV block diagnosis was present in 3,240 of DM patients (1.1%) vs 3,367 patients (0.6%) in the control group. Using multivariate analysis, DM remained strongly associated with third-degree AV block (odds ratio, 3.1; 95% confidential interval, 3.0 to 3.3; p < 0.0001). Conclusion: Third-degree AV block occurs significantly more in patients with DM. This finding may, in part, explain the high cardiovascular mortality in DM patients.

Original languageEnglish (US)
Pages (from-to)2611-2614
Number of pages4
JournalChest
Volume128
Issue number4
DOIs
StatePublished - Oct 2005
Externally publishedYes

Fingerprint

Atrioventricular Block
Type 2 Diabetes Mellitus
International Classification of Diseases
Diabetes Mellitus
Inpatients
Multivariate Analysis
Smoking
Veterans Health
United States Department of Veterans Affairs
Control Groups
Mortality
Hyperlipidemias
Coronary Artery Disease
Cardiovascular Diseases
Heart Failure
Odds Ratio
Databases
Hypertension
Therapeutics

Keywords

  • Arrhythmias
  • Atrioventricular block
  • Conduction abnormalities
  • Diabetes mellitus
  • Third-degree atrioventricular block

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Increased prevalence of third-degree atrioventricular block in patients with type II diabetes mellitus. / Movahed, Mohammad R; Hashemzadeh, Mehrtash; Jamal, M. Mazen.

In: Chest, Vol. 128, No. 4, 10.2005, p. 2611-2614.

Research output: Contribution to journalArticle

Movahed, Mohammad R ; Hashemzadeh, Mehrtash ; Jamal, M. Mazen. / Increased prevalence of third-degree atrioventricular block in patients with type II diabetes mellitus. In: Chest. 2005 ; Vol. 128, No. 4. pp. 2611-2614.
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