Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures IV: Chloramphenicol—urea system

Arthur H. Goldberg, Milo Gibaldi, Joseph L. Kanig, Michael Mayersohn

Research output: Contribution to journalArticle

109 Scopus citations

Abstract

The dissolution rates of a number of chloramphenicol‐urea samples were studied. Solubility studies indicated that urea increased significantly the solubility of chloramphenicol; this resulted in a large increase in the initial dissolution rate of chloramphenicol from physically mixed samples of the drug with urea. The α solid solution of chloramphenicol in urea was found to dissolve twice as rapidly as a physical mixture of the same composition, and almost 4 times as rapidly as the pure drug.

Original languageEnglish (US)
Pages (from-to)581-583
Number of pages3
JournalJournal of pharmaceutical sciences
Volume55
Issue number6
DOIs
StatePublished - Jun 1966

ASJC Scopus subject areas

  • Pharmaceutical Science

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