Increasing the antioxidant defense in WEHI7.2 cells results in a more tumor-like metabolic profile.

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Chronic inflammation is often associated with increased cancer frequency. Continuous exposure to reactive oxygen species, as at the site of chronic inflammation, can result in cells with increased antioxidant defense enzymes. In WEHI7.2 cells, overexpression of catalase or thioredoxin by transfection or selection of a cell population resistant to hydrogen peroxide has resulted in WEHI7.2 variants with altered glucose and energy metabolism. This metabolic change would favor survival in a tumor environment. We conclude that metabolic alterations, due to increased antioxidant enzyme expression, may underlie the increased tumorigenicity seen previously in the variants and contribute to the increased tumor risk associated with chronic inflammation.

Original languageEnglish (US)
Pages (from-to)497-501
Number of pages5
JournalInternational journal of molecular medicine
Volume15
Issue number3
StatePublished - Mar 2005

ASJC Scopus subject areas

  • Genetics

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