Independence of firing correlates of anatomically proximate hippocampal pyramidal cells.

A. D. Redish, F. P. Battaglia, M. K. Chawla, A. D. Ekstrom, J. L. Gerrard, P. Lipa, E. S. Rosenzweig, P. F. Worley, J. F. Guzowski, B. L. McNaughton, Carol A Barnes

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Abstract

In neocortex, neighboring neurons frequently exhibit correlated encoding properties. There is conflicting evidence whether a similar phenomenon occurs in hippocampus. To assess this quantitatively, a comparison was made of the spatial and temporal firing correlations within and between local groups of hippocampal cells, spaced 350-1400 microm apart. No evidence of clustering was found in a sample of >3000 neurons. Moreover, cells active in two environments were uniformly interspersed at a scale of <100 microm, as assessed by the activity-induced gene Arc. Independence of encoding characteristics implies uncorrelated inputs, which could enhance the capacity of the hippocampus to store arbitrary associations.

Original languageEnglish (US)
JournalJournal of Neuroscience
Volume21
Issue number5
StatePublished - 2001

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Pyramidal Cells
Hippocampus
Neurons
Neocortex
Cluster Analysis
Genes

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Redish, A. D., Battaglia, F. P., Chawla, M. K., Ekstrom, A. D., Gerrard, J. L., Lipa, P., ... Barnes, C. A. (2001). Independence of firing correlates of anatomically proximate hippocampal pyramidal cells. Journal of Neuroscience, 21(5).

Independence of firing correlates of anatomically proximate hippocampal pyramidal cells. / Redish, A. D.; Battaglia, F. P.; Chawla, M. K.; Ekstrom, A. D.; Gerrard, J. L.; Lipa, P.; Rosenzweig, E. S.; Worley, P. F.; Guzowski, J. F.; McNaughton, B. L.; Barnes, Carol A.

In: Journal of Neuroscience, Vol. 21, No. 5, 2001.

Research output: Contribution to journalArticle

Redish, AD, Battaglia, FP, Chawla, MK, Ekstrom, AD, Gerrard, JL, Lipa, P, Rosenzweig, ES, Worley, PF, Guzowski, JF, McNaughton, BL & Barnes, CA 2001, 'Independence of firing correlates of anatomically proximate hippocampal pyramidal cells.', Journal of Neuroscience, vol. 21, no. 5.
Redish AD, Battaglia FP, Chawla MK, Ekstrom AD, Gerrard JL, Lipa P et al. Independence of firing correlates of anatomically proximate hippocampal pyramidal cells. Journal of Neuroscience. 2001;21(5).
Redish, A. D. ; Battaglia, F. P. ; Chawla, M. K. ; Ekstrom, A. D. ; Gerrard, J. L. ; Lipa, P. ; Rosenzweig, E. S. ; Worley, P. F. ; Guzowski, J. F. ; McNaughton, B. L. ; Barnes, Carol A. / Independence of firing correlates of anatomically proximate hippocampal pyramidal cells. In: Journal of Neuroscience. 2001 ; Vol. 21, No. 5.
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AU - Gerrard, J. L.

AU - Lipa, P.

AU - Rosenzweig, E. S.

AU - Worley, P. F.

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