Induction and potentiation of lethal and genetic effects of ultraviolet light by tobacco smoke condensates in yeast

Mohammed A. Hannan, R. Scott Estes, Laurence Hurley

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Tobacco smoke condensates (TSC) were tested for DNA repair inhibition in both repair proficient and different classes of repair deficient strains of Saccharomyces cerevisiae. TSC was also tested for induction and potentiation of mutations and mitotic gene conversion in unirradiated and uv-irradiated yeast cells. TSC was found to sensitize all the strains of yeast to uv-inactivation indicating that it acts in a nonspecific manner and does not specifically inhibit a particular repair pathway. Genetic studies showed that TSC, without exogenous metabolic activation, failed to produce mutations while it induced mitotic gene conversion in the diploid strain. At specific concentrations, TSC potentiated both mutagenic and gene convertogenic effects uv-light while at higher concentrations of TSC a reduction of mutations was observed. The results are discussed as they relate to carcinogenesis and cocarcinogenesis/tumor promotion.

Original languageEnglish (US)
Pages (from-to)97-107
Number of pages11
JournalEnvironmental Research
Volume21
Issue number1
DOIs
StatePublished - 1980
Externally publishedYes

Fingerprint

Tobacco
Ultraviolet Rays
condensate
Smoke
Yeast
yeast
Yeasts
repair
Repair
mutation
Gene Conversion
Mutation
Cocarcinogenesis
gene
light effect
Diploidy
tumor
DNA Repair
Saccharomyces cerevisiae
genetic effect

ASJC Scopus subject areas

  • Environmental Science(all)

Cite this

Induction and potentiation of lethal and genetic effects of ultraviolet light by tobacco smoke condensates in yeast. / Hannan, Mohammed A.; Estes, R. Scott; Hurley, Laurence.

In: Environmental Research, Vol. 21, No. 1, 1980, p. 97-107.

Research output: Contribution to journalArticle

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