Induction of intestinal brush border alkaline phosphatase by vitamin D and identity with Ca-ATPase

Mark R. Haussler, Larry A. Nagode, Howard Rasmussen

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Abstract

VITAMIN D may increase the rate of intestinal transport of calcium through a primary action on nucleic acid and protein synthesis1,2. Wasserman and Taylor have detected a calcium binding protein in chick intestine which is induced by vitamin D3. Harmeyer and DeLuca, however, reported a discrepancy between the time course of change in calcium transport and of the increase in calcium binding protein4. In addition, calcium binding protein appears in the soluble portion of the cell3, whereas the major site of vitamin D action may be at the level of microvillar membrane 5,6. Thus, a comparison of isolated intestinal microvilli from vitamin D deficient and repleted animals might reveal other specific alterations which could be related to the action of vitamin D.

Original languageEnglish (US)
Pages (from-to)1199-1201
Number of pages3
JournalNature
Volume228
Issue number5277
DOIs
StatePublished - Dec 1 1970

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