Induction of intestinal brush border alkaline phosphatase by vitamin D and identity with Ca-ATPase

Mark R Haussler, Larry A. Nagode, Howard Rasmussen

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

VITAMIN D may increase the rate of intestinal transport of calcium through a primary action on nucleic acid and protein synthesis1,2. Wasserman and Taylor have detected a calcium binding protein in chick intestine which is induced by vitamin D3. Harmeyer and DeLuca, however, reported a discrepancy between the time course of change in calcium transport and of the increase in calcium binding protein4. In addition, calcium binding protein appears in the soluble portion of the cell3, whereas the major site of vitamin D action may be at the level of microvillar membrane 5,6. Thus, a comparison of isolated intestinal microvilli from vitamin D deficient and repleted animals might reveal other specific alterations which could be related to the action of vitamin D.

Original languageEnglish (US)
Pages (from-to)1199-1201
Number of pages3
JournalNature
Volume228
Issue number5277
DOIs
StatePublished - 1970
Externally publishedYes

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Microvilli
Vitamin D
Alkaline Phosphatase
Adenosine Triphosphatases
Calcium-Binding Proteins
Calcium
Cholecalciferol
Nucleic Acids
Intestines
Membranes
Proteins

ASJC Scopus subject areas

  • General

Cite this

Induction of intestinal brush border alkaline phosphatase by vitamin D and identity with Ca-ATPase. / Haussler, Mark R; Nagode, Larry A.; Rasmussen, Howard.

In: Nature, Vol. 228, No. 5277, 1970, p. 1199-1201.

Research output: Contribution to journalArticle

Haussler, Mark R ; Nagode, Larry A. ; Rasmussen, Howard. / Induction of intestinal brush border alkaline phosphatase by vitamin D and identity with Ca-ATPase. In: Nature. 1970 ; Vol. 228, No. 5277. pp. 1199-1201.
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