Induction of the proto-oncogene c-jun by angiotensin II

A. J. Naftilan, G. K. Gilliland, C. S. Eldridge, Andrew Kraft

Research output: Contribution to journalArticle

133 Scopus citations


Angiotensin (Ang) II causes hypertrophy of rat aortic smooth muscle cells in culture and results in the rapid activation of c-fos. This study demonstrated that Ang II also activated c-jun and, in addition, could activate the AP-1 enhancer element. These data add support for a role of Ang II as an important mediator of vascular smooth muscle cell growth.

Original languageEnglish (US)
Pages (from-to)5536-5540
Number of pages5
JournalMolecular and Cellular Biology
Issue number10
Publication statusPublished - 1990
Externally publishedYes


ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Naftilan, A. J., Gilliland, G. K., Eldridge, C. S., & Kraft, A. (1990). Induction of the proto-oncogene c-jun by angiotensin II. Molecular and Cellular Biology, 10(10), 5536-5540.