Inflammation biomarkers associated with arsenic exposure by drinking water and respiratory outcomes in indigenous children from three Yaqui villages in southern Sonora, México

Christian B. Vega-Millán, Ana G. Dévora-Figueroa, Jefferey L. Burgess, Paloma I. Beamer, Melissa Furlong, R. Clark Lantz, Diana Meza-Figueroa, Mary Kay O´Rourke, Leticia García-Rico, Edna R. Meza-Escalante, José J. Balderas-Cortés, Maria M. Meza-Montenegro

Research output: Contribution to journalArticlepeer-review

Abstract

Environmental arsenic exposure in adults and children has been associated with a reduction in the expression of club cell secretory protein (CC16) and an increase in the expression of matrix metalloproteinase-9 (MMP-9), both biomarkers of lung inflammation and negative respiratory outcomes. The objectives of this study were to determine if the levels of serum CC16 and MMP-9 and subsequent respiratory infections in children are associated with the ingestion of arsenic by drinking water. This cross-sectional study included 216 children from three Yaqui villages, Potam, Vicam, and Cocorit, with levels of arsenic in their ground water of 70.01 ± 21.85, 23.3 ± 9.99, and 11.8 ± 4.42 μg/L respectively. Total arsenic in water and urine samples was determined by inductively coupled plasma/optical emission spectrometry. Serum was analyzed for CC16 and MMP-9 using ELISA. The children had an average urinary arsenic of 79.39 μg/L and 46.8 % had levels above of the national concern value of 50 μg/L. Increased arsenic concentrations in drinking water and average daily arsenic intake by water were associated with decreased serum CC16 levels (β = − 0.12, 95% CI − 0.20, − 0.04 and β = − 0.10, 95% CI − 0.18, − 0.03), and increased serum MMP-9 levels (β = 0.35, 95% CI 0.22, 0.48 and β = 0.29, 95% CI 0.18, 0.40) at significant levels (P < 0.05). However, no association was found between levels of these serum biomarkers and urinary arsenic concentrations. In these children, reduced serum CC16 levels were significantly associated with increased risk of respiratory infections (OR = 0.34, 95% CI 0.13, 0.90). In conclusion, altered levels of serum CC16 and MMP-9 in the children may be due to the toxic effects of arsenic exposure through drinking water.

Original languageEnglish (US)
Pages (from-to)34355-34366
Number of pages12
JournalEnvironmental Science and Pollution Research
Volume28
Issue number26
DOIs
StatePublished - Jul 2021

Keywords

  • Arsenic
  • CC16
  • Drinking water
  • MMP-9
  • Respiratory infections
  • Yaqui children

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution
  • Health, Toxicology and Mutagenesis

Fingerprint

Dive into the research topics of 'Inflammation biomarkers associated with arsenic exposure by drinking water and respiratory outcomes in indigenous children from three Yaqui villages in southern Sonora, México'. Together they form a unique fingerprint.

Cite this