Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk

Hsin Jung Wu, Heloisa Sawaya, Bryce Binstadt, Margot Brickelmaier, Amanda Blasius, Leonid Gorelik, Umar Mahmood, Ralph Weissleder, John Carulli, Christophe Benoist, Diane Mathis

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Unmethylated CpG-oligodeoxynucleotides (ODNs) are generally thought of as potent adjuvants with considerable therapeutic potential to enhance immune responses against microbes and tumors. Surprisingly, certain so-called stimulatory CpG-ODNs strongly inhibited the effector phase of inflammatory arthritis in the K/BxN serum transfer system, either preventively or therapeutically. Also unexpected was that the inhibitory influence did not depend on the adaptive immune system cells mobilized in an immunostimulatory context. Instead, they relied on cells of the innate immune system, specifically on cross talk between CD8α+ dendritic cells and natural killer cells, resulting in suppression of neutrophil recruitment to the joint, orchestrated through interleukin-12 and interferon-γ. These findings highlight potential applications of CpG-ODNs and downstream molecules as antiinflammatory agents. JEM

Original languageEnglish (US)
Pages (from-to)1911-1922
Number of pages12
JournalJournal of Experimental Medicine
Volume204
Issue number8
DOIs
StatePublished - Aug 6 2007
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Wu, H. J., Sawaya, H., Binstadt, B., Brickelmaier, M., Blasius, A., Gorelik, L., Mahmood, U., Weissleder, R., Carulli, J., Benoist, C., & Mathis, D. (2007). Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk. Journal of Experimental Medicine, 204(8), 1911-1922. https://doi.org/10.1084/jem.20070285