Inflammatory bowel disease and the elderly: A Review

Sasha Taleban, Jean Frederic Colombel, Martha J Mohler, Mindy J Fain

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Inflammatory bowel disease among the elderly is common, with growing incident and prevalence rates. Compared with younger IBD patients, genetics contribute less to the pathogenesis of older-onset IBD, with dysbiosis and dysregulation of the immune system playing a more significant role. Diagnosis may be difficult in older individuals, as multiple other common diseases can mimic IBD in this population. The clinical manifestations in older-onset IBD are distinct, and patients tend to have less of a disease trajectory. Despite multiple effective medical and surgical treatment strategies for adults with Crohn's disease and ulcerative colitis, efficacy studies typically have excluded older subjects. A rapidly ageing population and increasing rates of Crohn's and ulcerative colitis make the paucity of data in older adults with IBD an increasingly important clinical issue. Copyright

Original languageEnglish (US)
Pages (from-to)507-515
Number of pages9
JournalJournal of Crohn's and Colitis
Volume9
Issue number6
DOIs
StatePublished - Jun 1 2015

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Ulcerative Colitis
Inflammatory Bowel Diseases
Dysbiosis
Crohn Disease
Population
Immune System
Therapeutics

Keywords

  • Elderly
  • Inflammatory bowel disease
  • Older

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

Inflammatory bowel disease and the elderly : A Review. / Taleban, Sasha; Colombel, Jean Frederic; Mohler, Martha J; Fain, Mindy J.

In: Journal of Crohn's and Colitis, Vol. 9, No. 6, 01.06.2015, p. 507-515.

Research output: Contribution to journalArticle

Taleban, Sasha ; Colombel, Jean Frederic ; Mohler, Martha J ; Fain, Mindy J. / Inflammatory bowel disease and the elderly : A Review. In: Journal of Crohn's and Colitis. 2015 ; Vol. 9, No. 6. pp. 507-515.
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