Influence of enteral feedings on phenytoin sodium absorption from capsules

L. Y. Nishimura, E. P. Armstrong, P. M. Plezia, R. P. Iacono

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The influence of enteral feeding (with Ensure) on the absorption of phenytoin sodium from capsules was studied. Six healthy and adult volunteers were given a single dose of phenytoin capsules 400 mg po on two occasions. Blood specimens were collected for 48 hours after each dose. In a randomized, crossover fashion, each subject completed the following two phases: (1) phenytoin without enteral feedings, and (2) concomitant enteral feedings before phenytoin and continued at 100 ml/h for ten hours. The areas under the concentration versus time curves from 0-48 hours (AUC0-48) were not significantly different between the two phases (p > 0.5). The percent relative bioavailability of phenytoin with enteral feedings was 101.7 percent. This study suggests that enteral feedings do not affect the serum concentrations of phenytoin after a single dose given in capsule form.

Original languageEnglish (US)
Pages (from-to)130-133
Number of pages4
JournalDrug Intelligence and Clinical Pharmacy
Volume22
Issue number2
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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