Influence of enteral feedings on phenytoin sodium absorption from capsules

L. Y. Nishimura, E. P. Armstrong, P. M. Plezia, R. P. Iacono

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The influence of enteral feeding (with Ensure) on the absorption of phenytoin sodium from capsules was studied. Six healthy and adult volunteers were given a single dose of phenytoin capsules 400 mg po on two occasions. Blood specimens were collected for 48 hours after each dose. In a randomized, crossover fashion, each subject completed the following two phases: (1) phenytoin without enteral feedings, and (2) concomitant enteral feedings before phenytoin and continued at 100 ml/h for ten hours. The areas under the concentration versus time curves from 0-48 hours (AUC0-48) were not significantly different between the two phases (p > 0.5). The percent relative bioavailability of phenytoin with enteral feedings was 101.7 percent. This study suggests that enteral feedings do not affect the serum concentrations of phenytoin after a single dose given in capsule form.

Original languageEnglish (US)
Pages (from-to)130-133
Number of pages4
JournalDrug Intelligence and Clinical Pharmacy
Volume22
Issue number2
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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