Influence of magnesium ion on human ventricular defibrillation after aortocoronary bypass surgery

Bernice R. Hecker, Carol L. Lake, Irving L. Kron, Robert M. Mentzer, Ivan K. Crosby, Stanton P. Nolan, Richard S. Crampton

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The administration of magnesium ion (Mg++) has been reported to defibrillate the ventricles and to decrease the incidence of arrhythmias after cardiopulmonary bypass. In a prospective study of 76 randomly selected patients undergoing coronary artery bypass grafting, patients received either no Mg++, 0.25 mEq/kg of Mg++ during cardiopulmonary bypass with the aorta clamped, or 0.375 mEq/kg of Mg++ before cardiopulmonary bypass. Spontaneous resumption of a cardiac rhythm or spontaneous defibrillation during reperfusion was not significantly affected by Mg++ administration. However, the number of shocks to initial and to sustained defibrillation and the energy required for the last direct-current shock was greatest in patients who received Mg++ before bypass and in those whose plasma Mg++ was greater than 2.26 mg/dl. Thus, the administration of Mg++ may have adverse effects on the heart if intraoperative plasma Mg++ exceeds 2.26 mg/dl.

Original languageEnglish (US)
Pages (from-to)61-64
Number of pages4
JournalThe American Journal of Cardiology
Volume55
Issue number1
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Cardiopulmonary Bypass
Coronary Artery Bypass
Magnesium
Ions
Shock
Reperfusion
Aorta
Cardiac Arrhythmias
Prospective Studies
Incidence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Influence of magnesium ion on human ventricular defibrillation after aortocoronary bypass surgery. / Hecker, Bernice R.; Lake, Carol L.; Kron, Irving L.; Mentzer, Robert M.; Crosby, Ivan K.; Nolan, Stanton P.; Crampton, Richard S.

In: The American Journal of Cardiology, Vol. 55, No. 1, 01.01.1985, p. 61-64.

Research output: Contribution to journalArticle

Hecker, Bernice R. ; Lake, Carol L. ; Kron, Irving L. ; Mentzer, Robert M. ; Crosby, Ivan K. ; Nolan, Stanton P. ; Crampton, Richard S. / Influence of magnesium ion on human ventricular defibrillation after aortocoronary bypass surgery. In: The American Journal of Cardiology. 1985 ; Vol. 55, No. 1. pp. 61-64.
@article{65d9941f86554e88ad0405119757d599,
title = "Influence of magnesium ion on human ventricular defibrillation after aortocoronary bypass surgery",
abstract = "The administration of magnesium ion (Mg++) has been reported to defibrillate the ventricles and to decrease the incidence of arrhythmias after cardiopulmonary bypass. In a prospective study of 76 randomly selected patients undergoing coronary artery bypass grafting, patients received either no Mg++, 0.25 mEq/kg of Mg++ during cardiopulmonary bypass with the aorta clamped, or 0.375 mEq/kg of Mg++ before cardiopulmonary bypass. Spontaneous resumption of a cardiac rhythm or spontaneous defibrillation during reperfusion was not significantly affected by Mg++ administration. However, the number of shocks to initial and to sustained defibrillation and the energy required for the last direct-current shock was greatest in patients who received Mg++ before bypass and in those whose plasma Mg++ was greater than 2.26 mg/dl. Thus, the administration of Mg++ may have adverse effects on the heart if intraoperative plasma Mg++ exceeds 2.26 mg/dl.",
author = "Hecker, {Bernice R.} and Lake, {Carol L.} and Kron, {Irving L.} and Mentzer, {Robert M.} and Crosby, {Ivan K.} and Nolan, {Stanton P.} and Crampton, {Richard S.}",
year = "1985",
month = "1",
day = "1",
doi = "10.1016/0002-9149(85)90300-5",
language = "English (US)",
volume = "55",
pages = "61--64",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Influence of magnesium ion on human ventricular defibrillation after aortocoronary bypass surgery

AU - Hecker, Bernice R.

AU - Lake, Carol L.

AU - Kron, Irving L.

AU - Mentzer, Robert M.

AU - Crosby, Ivan K.

AU - Nolan, Stanton P.

AU - Crampton, Richard S.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - The administration of magnesium ion (Mg++) has been reported to defibrillate the ventricles and to decrease the incidence of arrhythmias after cardiopulmonary bypass. In a prospective study of 76 randomly selected patients undergoing coronary artery bypass grafting, patients received either no Mg++, 0.25 mEq/kg of Mg++ during cardiopulmonary bypass with the aorta clamped, or 0.375 mEq/kg of Mg++ before cardiopulmonary bypass. Spontaneous resumption of a cardiac rhythm or spontaneous defibrillation during reperfusion was not significantly affected by Mg++ administration. However, the number of shocks to initial and to sustained defibrillation and the energy required for the last direct-current shock was greatest in patients who received Mg++ before bypass and in those whose plasma Mg++ was greater than 2.26 mg/dl. Thus, the administration of Mg++ may have adverse effects on the heart if intraoperative plasma Mg++ exceeds 2.26 mg/dl.

AB - The administration of magnesium ion (Mg++) has been reported to defibrillate the ventricles and to decrease the incidence of arrhythmias after cardiopulmonary bypass. In a prospective study of 76 randomly selected patients undergoing coronary artery bypass grafting, patients received either no Mg++, 0.25 mEq/kg of Mg++ during cardiopulmonary bypass with the aorta clamped, or 0.375 mEq/kg of Mg++ before cardiopulmonary bypass. Spontaneous resumption of a cardiac rhythm or spontaneous defibrillation during reperfusion was not significantly affected by Mg++ administration. However, the number of shocks to initial and to sustained defibrillation and the energy required for the last direct-current shock was greatest in patients who received Mg++ before bypass and in those whose plasma Mg++ was greater than 2.26 mg/dl. Thus, the administration of Mg++ may have adverse effects on the heart if intraoperative plasma Mg++ exceeds 2.26 mg/dl.

UR - http://www.scopus.com/inward/record.url?scp=0021993165&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021993165&partnerID=8YFLogxK

U2 - 10.1016/0002-9149(85)90300-5

DO - 10.1016/0002-9149(85)90300-5

M3 - Article

C2 - 3871301

AN - SCOPUS:0021993165

VL - 55

SP - 61

EP - 64

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 1

ER -