Mucosal fluid, sodium and chloride transfer were measured in everted sacs of rat, guinea pig and hamster jejunum, and in rat ileum and colon, and in guinea pig gall bladder. After treatment of the animal with ovine prolactin, a highly significant enhancement of fluid and NaCl absorption was observed in rat, hamster and guinea pig jejunum. Prolactin treatment caused a significant increase in fluid and NaCl transfer in rat ileum, but not in guinea pig ileum or rat colon. Prolactin administration had no consistent effect on fluid and NaCl absorption by the guinea pig gall bladder. The several regions of the mammalian gut appear to differ in their responsiveness to prolactin.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism