Influence of radioimmunoscintigraphy on postprostatectomy radiotherapy treatment decision making

Ashesh B. Jani, Michael J. Blend, Russell J Hamilton, Charles Brendler, Charles Pelizzari, Lani Krauz, Srinivasan Vijayakumar, Bipin Sapra, Azhar Awan, Ralph R. Weichselbaum

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The aim of this study was to evaluate the role of radioimmunoscintigraphy (RIS) directed against prostate-specific membrane antigen (PSMA) in influencing postradical retropubic prostatectomy (RRP) radiotherapy (RT) decision making. Methods: The records of consecutive patients who underwent RRP, who were referred for consideration of RT, and for whom an RIS scan was obtained were reviewed. The RT decisions, with regard to (a) the decision to offer RT and (b) the general volume to be treated [prostate fossa (PF) only versus PF + pelvis (P)] before knowledge of the RIS findings were charted. The RIS findings, with regard to uptake in the PF, uptake in the P, or extrapelvic (EP) uptake were tabulated. Then, the RT treatment decisions based on the RIS knowledge were evaluated and compared with the pre-RIS RT treatment decisions. Results: Of the 54 patients originally referred for post-RRP RT, the initial decision was to recommend RT to the PF only in 52 cases and to PF+P in 2 cases. The RIS findings were as follows: PF only, 43 patients; PF+P, 8 patients; PF+EP, 2 patients; PF+P+EP, 1 patient. After knowledge of these RIS results, the decision to offer RT was withdrawn in 4 of 54 patients (7.4%; P = 0.046). Furthermore, RIS changed the general treatment volume (PF only to PF+P) in 6 of 54 patients (11.1%; P = 0.015). In total, RIS altered the RT decision in 10 of 54 patients (18.5%; P = 0.0067). Three-year biochemical failure-free survival (with failure defined as 2 consecutive prostate-specific antigen [PSA] rises above 0.2 ng/mL after PSA nadir) was 78%; no patient, disease, or treatment factor reached statistical significance on univariate or multivariate analysis. Conclusion: RIS was found to influence post-RRP RT decision making for the identification of patients not likely to benefit from RT and for guiding general target volume definition.

Original languageEnglish (US)
Pages (from-to)571-578
Number of pages8
JournalJournal of Nuclear Medicine
Volume45
Issue number4
StatePublished - Apr 1 2004

Fingerprint

Radioimmunodetection
Decision Making
Radiotherapy
Prostate
Prostatectomy
Therapeutics
Prostate-Specific Antigen
Pelvis

Keywords

  • Prostate cancer
  • Prostatectomy
  • Radioimmunoscintigraphy
  • Radiotherapy

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Jani, A. B., Blend, M. J., Hamilton, R. J., Brendler, C., Pelizzari, C., Krauz, L., ... Weichselbaum, R. R. (2004). Influence of radioimmunoscintigraphy on postprostatectomy radiotherapy treatment decision making. Journal of Nuclear Medicine, 45(4), 571-578.

Influence of radioimmunoscintigraphy on postprostatectomy radiotherapy treatment decision making. / Jani, Ashesh B.; Blend, Michael J.; Hamilton, Russell J; Brendler, Charles; Pelizzari, Charles; Krauz, Lani; Vijayakumar, Srinivasan; Sapra, Bipin; Awan, Azhar; Weichselbaum, Ralph R.

In: Journal of Nuclear Medicine, Vol. 45, No. 4, 01.04.2004, p. 571-578.

Research output: Contribution to journalArticle

Jani, AB, Blend, MJ, Hamilton, RJ, Brendler, C, Pelizzari, C, Krauz, L, Vijayakumar, S, Sapra, B, Awan, A & Weichselbaum, RR 2004, 'Influence of radioimmunoscintigraphy on postprostatectomy radiotherapy treatment decision making', Journal of Nuclear Medicine, vol. 45, no. 4, pp. 571-578.
Jani, Ashesh B. ; Blend, Michael J. ; Hamilton, Russell J ; Brendler, Charles ; Pelizzari, Charles ; Krauz, Lani ; Vijayakumar, Srinivasan ; Sapra, Bipin ; Awan, Azhar ; Weichselbaum, Ralph R. / Influence of radioimmunoscintigraphy on postprostatectomy radiotherapy treatment decision making. In: Journal of Nuclear Medicine. 2004 ; Vol. 45, No. 4. pp. 571-578.
@article{1e1e9710e3dc4273830ed3b07d9b4aef,
title = "Influence of radioimmunoscintigraphy on postprostatectomy radiotherapy treatment decision making",
abstract = "The aim of this study was to evaluate the role of radioimmunoscintigraphy (RIS) directed against prostate-specific membrane antigen (PSMA) in influencing postradical retropubic prostatectomy (RRP) radiotherapy (RT) decision making. Methods: The records of consecutive patients who underwent RRP, who were referred for consideration of RT, and for whom an RIS scan was obtained were reviewed. The RT decisions, with regard to (a) the decision to offer RT and (b) the general volume to be treated [prostate fossa (PF) only versus PF + pelvis (P)] before knowledge of the RIS findings were charted. The RIS findings, with regard to uptake in the PF, uptake in the P, or extrapelvic (EP) uptake were tabulated. Then, the RT treatment decisions based on the RIS knowledge were evaluated and compared with the pre-RIS RT treatment decisions. Results: Of the 54 patients originally referred for post-RRP RT, the initial decision was to recommend RT to the PF only in 52 cases and to PF+P in 2 cases. The RIS findings were as follows: PF only, 43 patients; PF+P, 8 patients; PF+EP, 2 patients; PF+P+EP, 1 patient. After knowledge of these RIS results, the decision to offer RT was withdrawn in 4 of 54 patients (7.4{\%}; P = 0.046). Furthermore, RIS changed the general treatment volume (PF only to PF+P) in 6 of 54 patients (11.1{\%}; P = 0.015). In total, RIS altered the RT decision in 10 of 54 patients (18.5{\%}; P = 0.0067). Three-year biochemical failure-free survival (with failure defined as 2 consecutive prostate-specific antigen [PSA] rises above 0.2 ng/mL after PSA nadir) was 78{\%}; no patient, disease, or treatment factor reached statistical significance on univariate or multivariate analysis. Conclusion: RIS was found to influence post-RRP RT decision making for the identification of patients not likely to benefit from RT and for guiding general target volume definition.",
keywords = "Prostate cancer, Prostatectomy, Radioimmunoscintigraphy, Radiotherapy",
author = "Jani, {Ashesh B.} and Blend, {Michael J.} and Hamilton, {Russell J} and Charles Brendler and Charles Pelizzari and Lani Krauz and Srinivasan Vijayakumar and Bipin Sapra and Azhar Awan and Weichselbaum, {Ralph R.}",
year = "2004",
month = "4",
day = "1",
language = "English (US)",
volume = "45",
pages = "571--578",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "4",

}

TY - JOUR

T1 - Influence of radioimmunoscintigraphy on postprostatectomy radiotherapy treatment decision making

AU - Jani, Ashesh B.

AU - Blend, Michael J.

AU - Hamilton, Russell J

AU - Brendler, Charles

AU - Pelizzari, Charles

AU - Krauz, Lani

AU - Vijayakumar, Srinivasan

AU - Sapra, Bipin

AU - Awan, Azhar

AU - Weichselbaum, Ralph R.

PY - 2004/4/1

Y1 - 2004/4/1

N2 - The aim of this study was to evaluate the role of radioimmunoscintigraphy (RIS) directed against prostate-specific membrane antigen (PSMA) in influencing postradical retropubic prostatectomy (RRP) radiotherapy (RT) decision making. Methods: The records of consecutive patients who underwent RRP, who were referred for consideration of RT, and for whom an RIS scan was obtained were reviewed. The RT decisions, with regard to (a) the decision to offer RT and (b) the general volume to be treated [prostate fossa (PF) only versus PF + pelvis (P)] before knowledge of the RIS findings were charted. The RIS findings, with regard to uptake in the PF, uptake in the P, or extrapelvic (EP) uptake were tabulated. Then, the RT treatment decisions based on the RIS knowledge were evaluated and compared with the pre-RIS RT treatment decisions. Results: Of the 54 patients originally referred for post-RRP RT, the initial decision was to recommend RT to the PF only in 52 cases and to PF+P in 2 cases. The RIS findings were as follows: PF only, 43 patients; PF+P, 8 patients; PF+EP, 2 patients; PF+P+EP, 1 patient. After knowledge of these RIS results, the decision to offer RT was withdrawn in 4 of 54 patients (7.4%; P = 0.046). Furthermore, RIS changed the general treatment volume (PF only to PF+P) in 6 of 54 patients (11.1%; P = 0.015). In total, RIS altered the RT decision in 10 of 54 patients (18.5%; P = 0.0067). Three-year biochemical failure-free survival (with failure defined as 2 consecutive prostate-specific antigen [PSA] rises above 0.2 ng/mL after PSA nadir) was 78%; no patient, disease, or treatment factor reached statistical significance on univariate or multivariate analysis. Conclusion: RIS was found to influence post-RRP RT decision making for the identification of patients not likely to benefit from RT and for guiding general target volume definition.

AB - The aim of this study was to evaluate the role of radioimmunoscintigraphy (RIS) directed against prostate-specific membrane antigen (PSMA) in influencing postradical retropubic prostatectomy (RRP) radiotherapy (RT) decision making. Methods: The records of consecutive patients who underwent RRP, who were referred for consideration of RT, and for whom an RIS scan was obtained were reviewed. The RT decisions, with regard to (a) the decision to offer RT and (b) the general volume to be treated [prostate fossa (PF) only versus PF + pelvis (P)] before knowledge of the RIS findings were charted. The RIS findings, with regard to uptake in the PF, uptake in the P, or extrapelvic (EP) uptake were tabulated. Then, the RT treatment decisions based on the RIS knowledge were evaluated and compared with the pre-RIS RT treatment decisions. Results: Of the 54 patients originally referred for post-RRP RT, the initial decision was to recommend RT to the PF only in 52 cases and to PF+P in 2 cases. The RIS findings were as follows: PF only, 43 patients; PF+P, 8 patients; PF+EP, 2 patients; PF+P+EP, 1 patient. After knowledge of these RIS results, the decision to offer RT was withdrawn in 4 of 54 patients (7.4%; P = 0.046). Furthermore, RIS changed the general treatment volume (PF only to PF+P) in 6 of 54 patients (11.1%; P = 0.015). In total, RIS altered the RT decision in 10 of 54 patients (18.5%; P = 0.0067). Three-year biochemical failure-free survival (with failure defined as 2 consecutive prostate-specific antigen [PSA] rises above 0.2 ng/mL after PSA nadir) was 78%; no patient, disease, or treatment factor reached statistical significance on univariate or multivariate analysis. Conclusion: RIS was found to influence post-RRP RT decision making for the identification of patients not likely to benefit from RT and for guiding general target volume definition.

KW - Prostate cancer

KW - Prostatectomy

KW - Radioimmunoscintigraphy

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=2542494242&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2542494242&partnerID=8YFLogxK

M3 - Article

VL - 45

SP - 571

EP - 578

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 4

ER -