Influence of shape factors on kinetics of drug release from matrix tablets II: Experimental

John Cobby, Michael Mayersohn, George C. Walker

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Tablets were prepared from two slow‐release formulations, both containing stearyl alcohol as a homogeneous insoluble matrix. The release of salicylic acid and of ephedrine was measured in vitro. It was found that the release profiles could be described by a nonlinear expression for both cylindrical and biconvex tablets. Even though the rate of drug release varied noticeably with tablet shape, regression analysis of the release data indicated that the rate constants included in the expression did not vary significantly (p = 0.05) with shape for tablets of the same overall composition.

Original languageEnglish (US)
Pages (from-to)732-737
Number of pages6
JournalJournal of pharmaceutical sciences
Volume63
Issue number5
DOIs
StatePublished - May 1974

Keywords

  • Drug release from matrix tablets—experimental relationship between release and tablet shape, salicylic acid and ephedrine from stearyl alcohol
  • Tablets, slow release—release of salicylic acid and ephedrine from homogeneous insoluble matrix (stearyl alcohol), experimental relationship between release and tablet shape
  • Timed‐release tablets—slow release of salicylic acid and ephedrine from homogeneous insoluble matrix (stearyl alcohol), effect of tablet shape

ASJC Scopus subject areas

  • Pharmaceutical Science

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