Influence of shape factors on kinetics of drug release from matrix tablets I: Theoretical

John Cobby, Michael Mayersohn, George C. Walker

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

An expression having a basic cubic form was derived to describe the in vitro release of drugs from slow‐release tablets formulated with a homogeneous insoluble matrix. While the rate of drug release varies with tablet shape, rate constants that are independent of shape are included in the expression. By comparison with previously published work, it was shown that the rate constants may be described in terms of the physicochemical properties of the tablet constituents and the degree of compression. Therefore, it should be possible to evaluate the rate constants for model formulations and then, using the pertinent release expression, to predict the rate of drug release from tablets having identical compositions but varying widely in shape and size.

Original languageEnglish (US)
Pages (from-to)725-732
Number of pages8
JournalJournal of pharmaceutical sciences
Volume63
Issue number5
DOIs
StatePublished - May 1974

Keywords

  • Drug release from matrix tablets—relationship between release and tablet shape, theory, equations
  • Tablets, slow release—in vitro release from homogeneous insoluble matrix, theory and equations relating release and tablet shape
  • Timed‐release tablets—in vitro slow release from homogeneous insoluble matrix, effect of tablet shape, theory, equations

ASJC Scopus subject areas

  • Pharmaceutical Science

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