Influence of the level of dietary ethanol in mice with murine aids on resistance to streptococcus pneumoniae

L. Masoud Shahbazian, Amid R. Darban, Jill R. Darban, Antony M. Stazzone, Ronald R Watson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Chronic ethanol consumption impairs cellular immune functions. This may explain the increased occurrence of various opportunistic infections in heavy ethanol users. Immunological alterations associated with Acquired Immune Deficiency Syndrome (AIDS) also permit more opportunistic infections. In this study, we used a murine model of retrovirus infection induced by LP-BM5 murine leukemia virus. The combined effects of ethanol use and early retroviral infection (prior to the development of AIDS) on resistance to Streptococcus pneumoniae were investigated. Consumption of ethanol by non-retrovirus-infected mice resulted in decreased resistance to S. pneumoniae. However, retrovirus-infected mice fed a diet containing high concentrations of ethanol (6 and 7% v/v) exhibited a greater resistance to S. pneumoniae infection than retrovirus-infected mice fed diets with lower concentrations (5%) or no ethanol. The total number of white blood cells also decreased as serum ethanol levels increased. There were also fewer lymphocytes and more neutrophils and monocytes in retrovirus-infected mice fed ethanol. Diet consumption decreased as the concentration of ethanol increased in the diet. Consumption was dependent upon the dark-light cycle. The highest diet consumption was observed during the first 4 hr of the dark period. The level of ethanol in serum was influenced by the amount of the diet consumed and its ethanol concentration. Both retrovirus infection and ethanol consumption effected survival after S. pneumoniae infection.

Original languageEnglish (US)
Pages (from-to)345-352
Number of pages8
JournalAlcohol and Alcoholism
Volume27
Issue number4
StatePublished - Jul 1992

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Streptococcus pneumoniae
Ethanol
Nutrition
Diet
Retroviridae
Retroviridae Infections
Pneumococcal Infections
Opportunistic Infections
Acquired Immunodeficiency Syndrome
Murine Leukemia Viruses
Lymphocytes
Photoperiod
Serum
Viruses
Monocytes
Neutrophils
Leukocytes
Blood
Cells

ASJC Scopus subject areas

  • Toxicology
  • Psychiatry and Mental health
  • Medicine (miscellaneous)

Cite this

Influence of the level of dietary ethanol in mice with murine aids on resistance to streptococcus pneumoniae. / Shahbazian, L. Masoud; Darban, Amid R.; Darban, Jill R.; Stazzone, Antony M.; Watson, Ronald R.

In: Alcohol and Alcoholism, Vol. 27, No. 4, 07.1992, p. 345-352.

Research output: Contribution to journalArticle

Shahbazian, L. Masoud ; Darban, Amid R. ; Darban, Jill R. ; Stazzone, Antony M. ; Watson, Ronald R. / Influence of the level of dietary ethanol in mice with murine aids on resistance to streptococcus pneumoniae. In: Alcohol and Alcoholism. 1992 ; Vol. 27, No. 4. pp. 345-352.
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