Influenza in children with cancer

Allison Kempe, Caroline B. Hall, Noni E. MacDonald, Howard R. Foye, Kathleen A. Woodin, Harvey J. Cohen, Edward D. Lewis, Michelle Gullace, Christine L. Gala, Corinne S. Dulberg, Emmanuel Katsanis

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

We prospectively followed a group of unimmunized, immunosuppressed children with cancer to determine their relative risk of influenza and the severity of infection compared with those of siblings or matched community controls. The incidence of influenza infection was higher in children with cancer (23/73, 32%) than in control subjects (10/70, 14%, p=0.02). A preseason hemagglutination inhibition titer≥1:32, generally used as a marker of successful immunization in vaccine trials, was protective for all children in the control groups, but did not prevent influenza infection in 24% of the patients with cancer. Infection rates of patients and community controls with titers ≥1:32 differed significantly (p=0.006). No significant differences were noted in duration of reported symptoms between groups, and clinical complications occurred too infrequently to analyze. However, 2 (11%) of 18 of the cancer patients with positive culture results were hospitalized during the illness and one patient developed a nosocomial infection. None of the control children was hospitalized. These findings suggest the need for further study of the immunologic response of immunosuppressed children to influenza infection and a clinical efficacy trial of the influenza vaccine in these patients.

Original languageEnglish (US)
Pages (from-to)33-39
Number of pages7
JournalThe Journal of Pediatrics
Volume115
Issue number1
DOIs
StatePublished - 1989
Externally publishedYes

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Human Influenza
Infection
Neoplasms
Hospitalized Child
Influenza Vaccines
Hemagglutination
Cross Infection
Siblings
Immunization
Vaccines
Clinical Trials
Control Groups
Incidence

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Kempe, A., Hall, C. B., MacDonald, N. E., Foye, H. R., Woodin, K. A., Cohen, H. J., ... Katsanis, E. (1989). Influenza in children with cancer. The Journal of Pediatrics, 115(1), 33-39. https://doi.org/10.1016/S0022-3476(89)80325-7

Influenza in children with cancer. / Kempe, Allison; Hall, Caroline B.; MacDonald, Noni E.; Foye, Howard R.; Woodin, Kathleen A.; Cohen, Harvey J.; Lewis, Edward D.; Gullace, Michelle; Gala, Christine L.; Dulberg, Corinne S.; Katsanis, Emmanuel.

In: The Journal of Pediatrics, Vol. 115, No. 1, 1989, p. 33-39.

Research output: Contribution to journalArticle

Kempe, A, Hall, CB, MacDonald, NE, Foye, HR, Woodin, KA, Cohen, HJ, Lewis, ED, Gullace, M, Gala, CL, Dulberg, CS & Katsanis, E 1989, 'Influenza in children with cancer', The Journal of Pediatrics, vol. 115, no. 1, pp. 33-39. https://doi.org/10.1016/S0022-3476(89)80325-7
Kempe A, Hall CB, MacDonald NE, Foye HR, Woodin KA, Cohen HJ et al. Influenza in children with cancer. The Journal of Pediatrics. 1989;115(1):33-39. https://doi.org/10.1016/S0022-3476(89)80325-7
Kempe, Allison ; Hall, Caroline B. ; MacDonald, Noni E. ; Foye, Howard R. ; Woodin, Kathleen A. ; Cohen, Harvey J. ; Lewis, Edward D. ; Gullace, Michelle ; Gala, Christine L. ; Dulberg, Corinne S. ; Katsanis, Emmanuel. / Influenza in children with cancer. In: The Journal of Pediatrics. 1989 ; Vol. 115, No. 1. pp. 33-39.
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