Inhalable PEGylated phospholipid nanocarriers and PEGylated therapeutics for respiratory delivery as aerosolized colloidal dispersions and dry powder inhalers

Priya Muralidharan, Evan Mallory, Monica Malapit, Hayes Don, Heidi M. Mansour

Research output: Contribution to journalArticle

22 Scopus citations


Nanomedicine is making groundbreaking achievements in drug delivery. The versatility of nanoparticles has given rise to its use in respiratory delivery that includes inhalation aerosol delivery by the nasal route and the pulmonary route. Due to the unique features of the respiratory route, research in exploring the respiratory route for delivery of poorly absorbed and systemically unstable drugs has been increasing. The respiratory route has been successfully used for the delivery of macromolecules like proteins, peptides, and vaccines, and continues to be examined for use with small molecules, DNA, siRNA, and gene therapy. Phospholipid nanocarriers are an attractive drug delivery system for inhalation aerosol delivery in particular. Protecting these phospholipid nanocarriers from pulmonary immune system attack by surface modification by polyethylene glycol (PEG)ylation, enhancing mucopenetration by PEGylation, and sustaining drug release for controlled drug delivery are some of the advantages of PEGylated liposomal and proliposomal inhalation aerosol delivery. This review discusses the advantages of using PEGylated phospholipid nanocarriers and PEGylated therapeutics for respiratory delivery through the nasal and pulmonary routes as inhalation aerosols.

Original languageEnglish (US)
Pages (from-to)333-353
Number of pages21
Issue number2
Publication statusPublished - Jun 20 2014



  • Aerosol
  • Lung
  • Nasal
  • PEGylated inhalation powders
  • PEGylated liposomes
  • PEGylated micelles
  • Solid-state PEGylated bilayer nanocarriers
  • Sterically stabilized nanoparticles

ASJC Scopus subject areas

  • Pharmaceutical Science

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