Inhalation of an ethanol-based zileuton formulation provides a reduction of pulmonary adenomas in the A/J mouse model

Kelly L. Karlage, Erik Mogalian, Annikka Jensen, Paul B. Myrdal

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Potential efficacy of zileuton, a 5-LOX inhibitor, was evaluated for the reduction of pulmonary adenomas in the A/J murine model when administered via nose-only inhalation. Development of pulmonary adenomas was induced with benzo(a)pyrene. Animals were treated with a zileuton solution (5 mg/mL in 85:15 ethanol/water) either twice weekly or five times a week via nose-only inhalation; The placebo solution (85:15 EtOH/H2O, no active) was also evaluated. Dose delivered was calculated to be 1.2 mg/kg per exposure for each zileuton group. After 20 weeks of treatment, surface tumors were enumerated and histologically assessed. A significant reduction in tumor count was noted for both the twice weekly administration (40%) and the five times a week administration (59%). The data also showed a significant reduction for the group, which received the placebo (approximately 58%). The treatment groups were also found to have an impact on the histological stages of adenoma development.

Original languageEnglish (US)
Pages (from-to)168-173
Number of pages6
JournalAAPS PharmSciTech
Volume11
Issue number1
DOIs
StatePublished - Mar 1 2010

Keywords

  • Aerosol
  • Chemoprevention
  • Ethanol
  • Lung cancer
  • Zileuton

ASJC Scopus subject areas

  • Pharmaceutical Science

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