Inhaled atropine sulfate in acute asthma

Ronald D. Fairshter, Michael P. Habib, Archie F. Wilson

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We administered inhaled atropine sulfate to acute asthmatics already receiving therapeutic doses of adrenergic agonists, theophylline, and corticosteroids. Following atropine, hyperinflation diminished whereas vital capacity and expiratory flow rates breathing air and helium-oxygen increased (p < 0.025 – p < 0.005). Initial density dependence correlated inversely with changes in density dependence after atropine (r = – 0.69, p < 0.001). We conclude that: (1) inhaled atropine sulfate was effective therapy for acutely ill asthmatics already being treated with multiple antiasthmatic agents; (2) atropine caused large and peripheral airways bronchodilatation, and (3) the predominant site of bronchodilatation after atropine was related to the site of flow limitation before atropine.

Original languageEnglish (US)
Pages (from-to)263-272
Number of pages10
JournalRespiration
Volume42
Issue number4
DOIs
StatePublished - Jan 1 1981

Keywords

  • Asthma
  • Bronchodilatation
  • Inhaled atropine sulfate

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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