Inhibiting intracellular signalling as a strategy for cancer chemoprevention

G. Powis, D. S. Alberts

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The intracellular signalling pathways that mediate the effects of growth factors and oncogenes on cell growth and transformation offer potential targets for the development of chemopreventive agents that prevent the progression of premalignant cells to invasive cancer. Agents acting on signalling targets would be expected to be cytostatic rather than cytotoxic agents. A number of existing chemopreventive agents exhibit, among their properties, inhibition of intracellular signalling enzymes. It is possible that this activity accounts, at least in part, for their chemopreventive properties.

Original languageEnglish (US)
Pages (from-to)1138-1144
Number of pages7
JournalEuropean Journal of Cancer
Volume30
Issue number8
DOIs
StatePublished - 1994

Keywords

  • chemoprevention
  • growth factors
  • intracellular signalling
  • oncogenes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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