Inhibition of aspartic proteinases by propart peptides of human procathepsin D and chicken pepsinogen

M. Fusek, M. Mareš, J. Vágner, Z. Voburka, M. Baudyš

Research output: Contribution to journalArticle

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Abstract

Two propart peptides of aspartic proteinases. the propart peptide of chicken pepsin and human cathepsin D, respectively, were investigated from the point of view of their inhibitory activity for a set of aspartic proteinases. These peptides display a very broad inhibitory spectrum. The strongest inhibition was observed for pepsin A-like proteinases where propart peptides can be used as titrants of active enzymes.

Original languageEnglish (US)
Pages (from-to)160-162
Number of pages3
JournalFEBS Letters
Volume287
Issue number1-2
DOIs
StatePublished - Aug 5 1991
Externally publishedYes

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Keywords

  • Aspartic proteinase
  • Chicken pepsinogen: Inhibition
  • Human procathepsin D
  • Propart peptide
  • Zymogen activation

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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