Inhibition of COX-2 by celecoxib enhances glucocorticoid receptor function

F. Hu, X. Wang, Thaddeus Wesley Warren Pace, H. Wu, A. H. Miller

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Celecoxib is a widely used nonsteroidal anti-inflammatory agent that acts through selective inhibition of COX-2. Data presented in this paper demonstrated that celecoxib also significantly increased the functional activity of the glucocorticoid receptor, while inhibiting p38 mitogen-activated protein kinase. These results expand the intracellular targets of COX-2 inhibitors and widen their potential clinical application to disorders associated with impaired glucocorticoid function, including neuropsychiatric disorders such as major depression.

Original languageEnglish (US)
JournalMolecular Psychiatry
Volume10
Issue number5
DOIs
StatePublished - May 2005
Externally publishedYes

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Celecoxib
Glucocorticoid Receptors
Cyclooxygenase 2 Inhibitors
Non-Steroidal Anti-Inflammatory Agents
p38 Mitogen-Activated Protein Kinases
Glucocorticoids

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health

Cite this

Inhibition of COX-2 by celecoxib enhances glucocorticoid receptor function. / Hu, F.; Wang, X.; Pace, Thaddeus Wesley Warren; Wu, H.; Miller, A. H.

In: Molecular Psychiatry, Vol. 10, No. 5, 05.2005.

Research output: Contribution to journalArticle

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