Inhibition of COX-2 by celecoxib enhances glucocorticoid receptor function

F. Hu, X. Wang, T. W.W. Pace, H. Wu, A. H. Miller

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Celecoxib is a widely used nonsteroidal anti-inflammatory agent that acts through selective inhibition of COX-2. Data presented in this paper demonstrated that celecoxib also significantly increased the functional activity of the glucocorticoid receptor, while inhibiting p38 mitogen-activated protein kinase. These results expand the intracellular targets of COX-2 inhibitors and widen their potential clinical application to disorders associated with impaired glucocorticoid function, including neuropsychiatric disorders such as major depression.

Original languageEnglish (US)
Pages (from-to)426-428+423
JournalMolecular Psychiatry
Volume10
Issue number5
DOIs
StatePublished - May 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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