Inhibition of gastrin release by somatostatin in vitro

J. R. Hayes, D. G. Johnson, D. Koerker, R. H. Williams

Research output: Contribution to journalArticle

54 Scopus citations


An in vitro system which uses perifused pieces from the antrum of rat stomach has been used to study the effect of dihydrosomatostatin on gastrin release. The gastrin concentration in fractions of the perfusate was measured by radioimmunoassay. Dihydrosomatostatin (2 × 10−7M) had no effect on basal gastrin levels but virtually abolished the biphasic response seen with arginine stimulation. The study demonstrates close functional similarities between G cells and pancreatic islet cells.

Original languageEnglish (US)
Pages (from-to)1374-1376
Number of pages3
Issue number6
StatePublished - Jun 1975
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology

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