Inhibition of gastrin release by somatostatin in vitro

J. R. Hayes, David G Johnson, D. Koerker, R. H. Williams

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

An in vitro system which uses perfused pieces from the antrum of rat stomach has been used to study the effect of dihydrosomatostatin on gastrin release. The gastrin concentration in fractions of the perfusate was measured by radioimmunoassay. Dihydrosomatostatin (2 x 10-7 M) had no effect on basal gastrin levels but virtually abolished the biphasic response seen with arginine stimulation. The study demonstrates close functional similarities between G cells and pancreatic islet cells.

Original languageEnglish (US)
Pages (from-to)1374-1376
Number of pages3
JournalEndocrinology
Volume96
Issue number6
StatePublished - 1975
Externally publishedYes

Fingerprint

Gastrins
Somatostatin
Islets of Langerhans
Gastrin-Secreting Cells
Radioimmunoassay
Arginine
Stomach
In Vitro Techniques
dihydrosomatostatin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Hayes, J. R., Johnson, D. G., Koerker, D., & Williams, R. H. (1975). Inhibition of gastrin release by somatostatin in vitro. Endocrinology, 96(6), 1374-1376.

Inhibition of gastrin release by somatostatin in vitro. / Hayes, J. R.; Johnson, David G; Koerker, D.; Williams, R. H.

In: Endocrinology, Vol. 96, No. 6, 1975, p. 1374-1376.

Research output: Contribution to journalArticle

Hayes, JR, Johnson, DG, Koerker, D & Williams, RH 1975, 'Inhibition of gastrin release by somatostatin in vitro', Endocrinology, vol. 96, no. 6, pp. 1374-1376.
Hayes JR, Johnson DG, Koerker D, Williams RH. Inhibition of gastrin release by somatostatin in vitro. Endocrinology. 1975;96(6):1374-1376.
Hayes, J. R. ; Johnson, David G ; Koerker, D. ; Williams, R. H. / Inhibition of gastrin release by somatostatin in vitro. In: Endocrinology. 1975 ; Vol. 96, No. 6. pp. 1374-1376.
@article{f5f462ed65c347279dae461f20cd1b83,
title = "Inhibition of gastrin release by somatostatin in vitro",
abstract = "An in vitro system which uses perfused pieces from the antrum of rat stomach has been used to study the effect of dihydrosomatostatin on gastrin release. The gastrin concentration in fractions of the perfusate was measured by radioimmunoassay. Dihydrosomatostatin (2 x 10-7 M) had no effect on basal gastrin levels but virtually abolished the biphasic response seen with arginine stimulation. The study demonstrates close functional similarities between G cells and pancreatic islet cells.",
author = "Hayes, {J. R.} and Johnson, {David G} and D. Koerker and Williams, {R. H.}",
year = "1975",
language = "English (US)",
volume = "96",
pages = "1374--1376",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "6",

}

TY - JOUR

T1 - Inhibition of gastrin release by somatostatin in vitro

AU - Hayes, J. R.

AU - Johnson, David G

AU - Koerker, D.

AU - Williams, R. H.

PY - 1975

Y1 - 1975

N2 - An in vitro system which uses perfused pieces from the antrum of rat stomach has been used to study the effect of dihydrosomatostatin on gastrin release. The gastrin concentration in fractions of the perfusate was measured by radioimmunoassay. Dihydrosomatostatin (2 x 10-7 M) had no effect on basal gastrin levels but virtually abolished the biphasic response seen with arginine stimulation. The study demonstrates close functional similarities between G cells and pancreatic islet cells.

AB - An in vitro system which uses perfused pieces from the antrum of rat stomach has been used to study the effect of dihydrosomatostatin on gastrin release. The gastrin concentration in fractions of the perfusate was measured by radioimmunoassay. Dihydrosomatostatin (2 x 10-7 M) had no effect on basal gastrin levels but virtually abolished the biphasic response seen with arginine stimulation. The study demonstrates close functional similarities between G cells and pancreatic islet cells.

UR - http://www.scopus.com/inward/record.url?scp=0016756799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016756799&partnerID=8YFLogxK

M3 - Article

C2 - 1126310

AN - SCOPUS:0016756799

VL - 96

SP - 1374

EP - 1376

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 6

ER -