Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor

Patrick W. Mantyh, Scott D. Rogers, Prisca Honore, Brian J. Allen, Joseph R. Ghilardi, Jun Li, Randy S. Daughters, Douglas A. Lappi, Ronald G. Wiley, Donald A. Simone

Research output: Contribution to journalArticlepeer-review

491 Scopus citations

Abstract

Substance P is released in the spinal cord in response to painful stimuli, but its role in nociceptive signaling remains unclear. When a conjugate of substance P and the ribosome-inactivating protein saporin was infused into the spinal cord, it was internalized and cytotoxic to lamina I spinal cord neurons that express the substance P receptor. This treatment left responses to mild noxious stimuli unchanged, but markedly attenuated responses to highly noxious stimuli and mechanical and thermal hyperalgesia. Thus, lamina I spinal cord neurons that express the substance P receptor play a pivotal role in the transmission of highly noxious stimuli and the maintenance of hyperalgesia.

Original languageEnglish (US)
Pages (from-to)275-279
Number of pages5
JournalScience
Volume278
Issue number5336
DOIs
StatePublished - Oct 10 1997

ASJC Scopus subject areas

  • General

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