Inhibition of immune responses in vitro by specific antiserums to Ia antigens

Jeffrey A Frelinger, John E. Niederhuber, Donald C. Shreffler

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Mouse antiserums prepared against la antigens, which are products of I (immune reponse) region genes of the H-2 complex, can inhibit both primary (immunoglobulin M) and secondary (immunoglobulin G) immune responses in vitro by mouse spleen cultures to heterologous erythrocytes. Antiserums directed specifically at products of either the H-2K or H-2D loci have no effect on this response.

Original languageEnglish (US)
Pages (from-to)268-270
Number of pages3
JournalScience
Volume188
Issue number4185
StatePublished - 1975
Externally publishedYes

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Histocompatibility Antigens Class II
Immune Sera
Immunoglobulin M
Spleen
Immunoglobulin G
Erythrocytes
Antigens
Genes
In Vitro Techniques

ASJC Scopus subject areas

  • General

Cite this

Frelinger, J. A., Niederhuber, J. E., & Shreffler, D. C. (1975). Inhibition of immune responses in vitro by specific antiserums to Ia antigens. Science, 188(4185), 268-270.

Inhibition of immune responses in vitro by specific antiserums to Ia antigens. / Frelinger, Jeffrey A; Niederhuber, John E.; Shreffler, Donald C.

In: Science, Vol. 188, No. 4185, 1975, p. 268-270.

Research output: Contribution to journalArticle

Frelinger, JA, Niederhuber, JE & Shreffler, DC 1975, 'Inhibition of immune responses in vitro by specific antiserums to Ia antigens', Science, vol. 188, no. 4185, pp. 268-270.
Frelinger, Jeffrey A ; Niederhuber, John E. ; Shreffler, Donald C. / Inhibition of immune responses in vitro by specific antiserums to Ia antigens. In: Science. 1975 ; Vol. 188, No. 4185. pp. 268-270.
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