Inhibition of immune responses in vitro by specific antiserums to Ia antigens

Jeffrey A. Frelinger; John E. Niederhuber; Donald C. Shreffler

doi:10.1126/science.1118728

Inhibition of immune responses in vitro by specific antiserums to Ia antigens

Jeffrey A. Frelinger, John E. Niederhuber, Donald C. Shreffler

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55 Scopus citations

Abstract

Mouse antiserums prepared against la antigens, which are products of I (immune reponse) region genes of the H-2 complex, can inhibit both primary (immunoglobulin M) and secondary (immunoglobulin G) immune responses in vitro by mouse spleen cultures to heterologous erythrocytes. Antiserums directed specifically at products of either the H-2K or H-2D loci have no effect on this response.

Original language	English (US)
Pages (from-to)	268-270
Number of pages	3
Journal	Science
Volume	188
Issue number	4185
DOIs	https://doi.org/10.1126/science.1118728
State	Published - Jan 1 1975
Externally published	Yes

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abstract = "Mouse antiserums prepared against la antigens, which are products of I (immune reponse) region genes of the H-2 complex, can inhibit both primary (immunoglobulin M) and secondary (immunoglobulin G) immune responses in vitro by mouse spleen cultures to heterologous erythrocytes. Antiserums directed specifically at products of either the H-2K or H-2D loci have no effect on this response.",

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