Inhibition of immune responses in vitro by specific antiserums to Ia antigens

Jeffrey A. Frelinger, John E. Niederhuber, Donald C. Shreffler

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Mouse antiserums prepared against la antigens, which are products of I (immune reponse) region genes of the H-2 complex, can inhibit both primary (immunoglobulin M) and secondary (immunoglobulin G) immune responses in vitro by mouse spleen cultures to heterologous erythrocytes. Antiserums directed specifically at products of either the H-2K or H-2D loci have no effect on this response.

Original languageEnglish (US)
Pages (from-to)268-270
Number of pages3
JournalScience
Volume188
Issue number4185
DOIs
StatePublished - Jan 1 1975
Externally publishedYes

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