Inhibition of norfloxacin absorption by antacids

David E. Nix, J. H. Wilton, B. Ronald, L. Distlerath, V. C. Williams, A. Norman

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

The effects of antacids on the systemic absorption of oral norfloxacin was evaluated in 12 healthy volunteers. Subjects were given each treatment in a balanced sequence at 7-day intervals. Treatments included 400 mg of norfloxacin alone, 400 mg of norfloxacin 5 min after aluminium-magnesium hydroxide (Maalox), Maalox 2 h after 400 mg of norfloxacin, and 400 mg of norfloxacin 5 min after calcium carbonate (Titralac). Blood and urine samples were collected at predetermined time intervals for 24 and 48 h, respectively. Norfloxacin concentrations in plasma and urine were determined by high-pressure liquid chromatography. The area under the plasma concentration-versus-time curve from time zero to infinity and urinary recovery were used to compare the relative bioavailability of norfloxacin with antacids with that of norfloxacin alone. Norfloxacin bioavailability was markedly reduced when subjects received antacid pretreatment. When norfloxacin was given 5 min after Maalox and Titralac, the bioavailabilities were 9.02 and 37.5%, respectively, relative to that for 400 mg of norfloxacin alone. When Maalox was given 2 h after norfloxacin, maximal concentrations of norfloxacin in plasma occurred between 1 and 1.5 h postdose, and absorption was reduced to a lesser extent, with a relative bioavailability of 81.31%. Norfloxacin concentrations in urine were also reduced as a result of antacid administration. Antacids containing aluminium and magnesium salts and calcium carbonate should be avoided by patients taking norfloxacin.

Original languageEnglish (US)
Pages (from-to)432-435
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume34
Issue number3
StatePublished - 1990
Externally publishedYes

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Norfloxacin
Antacids
Biological Availability
Urine
Calcium Carbonate
Aluminum

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Nix, D. E., Wilton, J. H., Ronald, B., Distlerath, L., Williams, V. C., & Norman, A. (1990). Inhibition of norfloxacin absorption by antacids. Antimicrobial Agents and Chemotherapy, 34(3), 432-435.

Inhibition of norfloxacin absorption by antacids. / Nix, David E.; Wilton, J. H.; Ronald, B.; Distlerath, L.; Williams, V. C.; Norman, A.

In: Antimicrobial Agents and Chemotherapy, Vol. 34, No. 3, 1990, p. 432-435.

Research output: Contribution to journalArticle

Nix, DE, Wilton, JH, Ronald, B, Distlerath, L, Williams, VC & Norman, A 1990, 'Inhibition of norfloxacin absorption by antacids', Antimicrobial Agents and Chemotherapy, vol. 34, no. 3, pp. 432-435.
Nix DE, Wilton JH, Ronald B, Distlerath L, Williams VC, Norman A. Inhibition of norfloxacin absorption by antacids. Antimicrobial Agents and Chemotherapy. 1990;34(3):432-435.
Nix, David E. ; Wilton, J. H. ; Ronald, B. ; Distlerath, L. ; Williams, V. C. ; Norman, A. / Inhibition of norfloxacin absorption by antacids. In: Antimicrobial Agents and Chemotherapy. 1990 ; Vol. 34, No. 3. pp. 432-435.
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