Inhibitory synchrony as a mechanism for attentional gain modulation

Paul H. Tiesinga, Jean Marc Fellous, Emilio Salinas, Jorge V. José, Terrence J. Sejnowski

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

Recordings from area V4 of monkeys have revealed that when the focus of attention is on a visual stimulus within the receptive field of a cortical neuron, two distinct changes can occur: The firing rate of the neuron can change and there can be an increase in the coherence between spikes and the local field potential (LFP) in the gamma-frequency range (30-50 Hz). The hypothesis explored here is that these observed effects of attention could be a consequence of changes in the synchrony of local interneuron networks. We performed computer simulations of a Hodgkin-Huxley type neuron driven by a constant depolarizing current, I, representing visual stimulation and a modulatory inhibitory input representing the effects of attention via local interneuron networks. We observed that the neuron's firing rate and the coherence of its output spike train with the synaptic inputs was modulated by the degree of synchrony of the inhibitory inputs. When inhibitory synchrony increased, the coherence of spiking model neurons with the synaptic input increased, but the firing rate either increased or remained the same. The mean number of synchronous inhibitory inputs was a key determinant of the shape of the firing rate versus current (f-I) curves. For a large number of inhibitory inputs (∼50), the f-I curve saturated for large I and an increase in input synchrony resulted in a shift of sensitivity-the model neuron responded to weaker inputs I. For a small number (∼10), the f-I curves were non-saturating and an increase in input synchrony led to an increase in the gain of the response-the firing rate in response to the same input was multiplied by an approximately constant factor. The firing rate modulation with inhibitory synchrony was highest when the input network oscillated in the gamma frequency range. Thus, the observed changes in firing rate and coherence of neurons in the visual cortex could be controlled by top-down inputs that regulated the coherence in the activity of a local inhibitory network discharging at gamma frequencies.

Original languageEnglish (US)
Pages (from-to)296-314
Number of pages19
JournalJournal of Physiology Paris
Volume98
Issue number4-6 SPEC. ISS.
DOIs
StatePublished - Jul 2004
Externally publishedYes

Keywords

  • Computer model
  • Gain modulation
  • Gamma oscillation
  • Noise
  • Selective attention
  • Synchrony

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

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