Innate immunity

Sensing the environment and regulating the regulators

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Purpose of review: Innate immune cells act as sensors for environmental pathogens and key regulators of pathogen-specific T-cell effector responses. The expression of Toll-like receptors is essential for these functions. Innate immunity is a rapidly evolving field. Great progress has been made in the past year in characterizing the signaling pathways downstream of Toll-like receptors, and the role of Toll-like receptors in the regulation of pathogen responses. Recent findings: The ability to control the activation of regulatory T cells has emerged as a key function of innate immunity. Regulatory T cells are involved in the induction of tolerance and the prevention of harmful immune pathology, particularly T-cell responses directed against self-antigens. Toll-like receptor-mediated interactions between pathogen-stimulated innate immune cells and regulatory T cells result in the release of suppression by regulatory T cells, thus allowing pathogen-specific responses. However, pathogenic microorganisms may exploit this interaction to evade the host's response. In addition, recent studies raise the possibility that regulatory T cells may express some Toll-like receptor family members, thereby responding directly to pathogens. Summary: A deeper understanding of the complex role of innate immune cells as sensors of the environment and regulators of pathogen responses will probably influence the current models of immune regulation, particularly those centered on the role of the environment in shaping immune responses.

Original languageEnglish (US)
Pages (from-to)343-346
Number of pages4
JournalCurrent Opinion in Allergy and Clinical Immunology
Volume3
Issue number5
DOIs
StatePublished - Oct 2003

Fingerprint

Toll-Like Receptors
Regulatory T-Lymphocytes
Innate Immunity
T-Lymphocytes
Aptitude
Autoantigens
Pathology

Keywords

  • Dendritic cells
  • Innate immunity
  • Regulatory T cells
  • Toll-like receptors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Innate immunity : Sensing the environment and regulating the regulators. / Vercelli, Donata.

In: Current Opinion in Allergy and Clinical Immunology, Vol. 3, No. 5, 10.2003, p. 343-346.

Research output: Contribution to journalArticle

@article{2e4af9ad293247238ca4a93e110d1bf7,
title = "Innate immunity: Sensing the environment and regulating the regulators",
abstract = "Purpose of review: Innate immune cells act as sensors for environmental pathogens and key regulators of pathogen-specific T-cell effector responses. The expression of Toll-like receptors is essential for these functions. Innate immunity is a rapidly evolving field. Great progress has been made in the past year in characterizing the signaling pathways downstream of Toll-like receptors, and the role of Toll-like receptors in the regulation of pathogen responses. Recent findings: The ability to control the activation of regulatory T cells has emerged as a key function of innate immunity. Regulatory T cells are involved in the induction of tolerance and the prevention of harmful immune pathology, particularly T-cell responses directed against self-antigens. Toll-like receptor-mediated interactions between pathogen-stimulated innate immune cells and regulatory T cells result in the release of suppression by regulatory T cells, thus allowing pathogen-specific responses. However, pathogenic microorganisms may exploit this interaction to evade the host's response. In addition, recent studies raise the possibility that regulatory T cells may express some Toll-like receptor family members, thereby responding directly to pathogens. Summary: A deeper understanding of the complex role of innate immune cells as sensors of the environment and regulators of pathogen responses will probably influence the current models of immune regulation, particularly those centered on the role of the environment in shaping immune responses.",
keywords = "Dendritic cells, Innate immunity, Regulatory T cells, Toll-like receptors",
author = "Donata Vercelli",
year = "2003",
month = "10",
doi = "10.1097/00130832-200310000-00004",
language = "English (US)",
volume = "3",
pages = "343--346",
journal = "Current Opinion in Allergy and Clinical Immunology",
issn = "1528-4050",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Innate immunity

T2 - Sensing the environment and regulating the regulators

AU - Vercelli, Donata

PY - 2003/10

Y1 - 2003/10

N2 - Purpose of review: Innate immune cells act as sensors for environmental pathogens and key regulators of pathogen-specific T-cell effector responses. The expression of Toll-like receptors is essential for these functions. Innate immunity is a rapidly evolving field. Great progress has been made in the past year in characterizing the signaling pathways downstream of Toll-like receptors, and the role of Toll-like receptors in the regulation of pathogen responses. Recent findings: The ability to control the activation of regulatory T cells has emerged as a key function of innate immunity. Regulatory T cells are involved in the induction of tolerance and the prevention of harmful immune pathology, particularly T-cell responses directed against self-antigens. Toll-like receptor-mediated interactions between pathogen-stimulated innate immune cells and regulatory T cells result in the release of suppression by regulatory T cells, thus allowing pathogen-specific responses. However, pathogenic microorganisms may exploit this interaction to evade the host's response. In addition, recent studies raise the possibility that regulatory T cells may express some Toll-like receptor family members, thereby responding directly to pathogens. Summary: A deeper understanding of the complex role of innate immune cells as sensors of the environment and regulators of pathogen responses will probably influence the current models of immune regulation, particularly those centered on the role of the environment in shaping immune responses.

AB - Purpose of review: Innate immune cells act as sensors for environmental pathogens and key regulators of pathogen-specific T-cell effector responses. The expression of Toll-like receptors is essential for these functions. Innate immunity is a rapidly evolving field. Great progress has been made in the past year in characterizing the signaling pathways downstream of Toll-like receptors, and the role of Toll-like receptors in the regulation of pathogen responses. Recent findings: The ability to control the activation of regulatory T cells has emerged as a key function of innate immunity. Regulatory T cells are involved in the induction of tolerance and the prevention of harmful immune pathology, particularly T-cell responses directed against self-antigens. Toll-like receptor-mediated interactions between pathogen-stimulated innate immune cells and regulatory T cells result in the release of suppression by regulatory T cells, thus allowing pathogen-specific responses. However, pathogenic microorganisms may exploit this interaction to evade the host's response. In addition, recent studies raise the possibility that regulatory T cells may express some Toll-like receptor family members, thereby responding directly to pathogens. Summary: A deeper understanding of the complex role of innate immune cells as sensors of the environment and regulators of pathogen responses will probably influence the current models of immune regulation, particularly those centered on the role of the environment in shaping immune responses.

KW - Dendritic cells

KW - Innate immunity

KW - Regulatory T cells

KW - Toll-like receptors

UR - http://www.scopus.com/inward/record.url?scp=0141988981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141988981&partnerID=8YFLogxK

U2 - 10.1097/00130832-200310000-00004

DO - 10.1097/00130832-200310000-00004

M3 - Article

VL - 3

SP - 343

EP - 346

JO - Current Opinion in Allergy and Clinical Immunology

JF - Current Opinion in Allergy and Clinical Immunology

SN - 1528-4050

IS - 5

ER -