Insertion sequence duplication in transpositional recombination

Ted A. Weinert, Nancy A. Schaus, Nigel D.F. Grindley

Research output: Contribution to journalArticle

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Abstract

Insertion sequences (IS) are discrete segments of DNA that can transpose from one genomic site to another and promote genetic rearrangements. A question that is central to understanding the mechanism of transpositional recombination is whether genetic rearrangements are accompanied by duplication of the IS that promotes them. Analysis of adjacent deletions mediated by IS903 provides the strongest evidence to date than any IS-mediated transpositional recombination can occur by an efficient replicative mechanism.

Original languageEnglish (US)
Pages (from-to)755-765
Number of pages11
JournalScience
Volume222
Issue number4625
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

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ASJC Scopus subject areas

  • General

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