Instrument for the measurement of retinal vessel oxygen saturation

Jonathan Drewes, Matthew Smith, Kurt R Denninghoff, Lloyd Hillman

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Citations (Scopus)

Abstract

Retinal vessel oxygen saturation has been suggested as a parameter for monitoring a wide range of conditions including occult blood loss and a variety of ophthalmic diseases. We have developed an Eye Oximeter (EOX), that noninvasively measures the oxygen saturation of the blood in individual large retinal vessels using scanning lasers. One-dimensional vessel extinction profiles are obtained at four wavelengths (629, 678, 821 and 899 nm), and the vessel transmittances computed. The oxygen saturation of blood within the vessel is then calculated from the transmittance data. We have performed an in vitro experiment on human blood which demonstrates the calibration of the EOX measurement and validates our oximetry equations. Retinal vessel oxygen saturation was measured in a human subject and found to be 65%O2Sat and 101-102%O2Sat in the veins and arteries on the optic disk. Irregularities in the background measured away from the optic disk resulted in a larger variance in the calculated saturation when compared to measurements made on the disk.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages114-120
Number of pages7
Volume3591
StatePublished - 1999
Externally publishedYes
EventProceedings of the 1999 Ophthalmic Technologies IX - San Jose, CA, USA
Duration: Jan 23 1999Jan 25 1999

Other

OtherProceedings of the 1999 Ophthalmic Technologies IX
CitySan Jose, CA, USA
Period1/23/991/25/99

Fingerprint

vessels
Blood
Oximeters
saturation
blood
Oxygen
oxygen
Optics
transmittance
oximetry
optics
Calibration
arteries
Scanning
irregularities
veins
Wavelength
Lasers
Monitoring
extinction

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Drewes, J., Smith, M., Denninghoff, K. R., & Hillman, L. (1999). Instrument for the measurement of retinal vessel oxygen saturation. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3591, pp. 114-120). Society of Photo-Optical Instrumentation Engineers.

Instrument for the measurement of retinal vessel oxygen saturation. / Drewes, Jonathan; Smith, Matthew; Denninghoff, Kurt R; Hillman, Lloyd.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3591 Society of Photo-Optical Instrumentation Engineers, 1999. p. 114-120.

Research output: Chapter in Book/Report/Conference proceedingChapter

Drewes, J, Smith, M, Denninghoff, KR & Hillman, L 1999, Instrument for the measurement of retinal vessel oxygen saturation. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3591, Society of Photo-Optical Instrumentation Engineers, pp. 114-120, Proceedings of the 1999 Ophthalmic Technologies IX, San Jose, CA, USA, 1/23/99.
Drewes J, Smith M, Denninghoff KR, Hillman L. Instrument for the measurement of retinal vessel oxygen saturation. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3591. Society of Photo-Optical Instrumentation Engineers. 1999. p. 114-120
Drewes, Jonathan ; Smith, Matthew ; Denninghoff, Kurt R ; Hillman, Lloyd. / Instrument for the measurement of retinal vessel oxygen saturation. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3591 Society of Photo-Optical Instrumentation Engineers, 1999. pp. 114-120
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