Insulin binding to cells of several tissues of the early chick embryo

Thomas C. Doetschman, Amalia S. Havaranis, Heinz Herrmann

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The binding of I125-labeled insulin to isolated cells from several tissues of the 3- and 4-day chick embryo was determined over a concentration range of insulin from 2 × 10-11 to 2 × 10-7 M. The cells were obtained from limb bud and nonlimb bud tissues of the 4-day chick, from the headless 3-day chick embryo, and from cartilage of the 12-day embryo. The amount of bound insulin was found to be similar for the cells from the different embryonic tissues. Some implications of these findings for the interpretation of the nature of the binding sites and the teratogenic effect of insulin are discussed.

Original languageEnglish (US)
Pages (from-to)228-232
Number of pages5
JournalDevelopmental biology
Volume47
Issue number1
DOIs
StatePublished - Nov 1975
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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