Insulin-like growth factors-I and -II, somatotropin, prolactin, and placental lactogen are not acute effectors of lipolysis in ruminants

K. L. Houseknecht, D. E. Bauman, R. G. Vernon, J. C. Byatt, Robert J Collier

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The acute regulation of lipolysis in the adipose tissue of ruminants was evaluated with lactating cows (n = 4) and growing ewe lambs (n = 11). Subcutaneous adipose tissue was obtained by biopsy or at slaughter and was incubated with varying concentrations of biologically active insulin-like growth factors-I and -II (IGF-I, IGF-II), somatotropin (ST), prolactin (PRL), or placental lactogen (PL) to determine the effect of these hormones on lipolysis. Complimentary studies were conducted to examine the effects of IGF-I and IGF-II on the acute regulation of lipolysis in adipose tissue from lactating ewes and wethers under a variety of incubation conditions. Isoproterenol (ISO), a β-adrenergic agonist known to rapidly stimulate lipolysis, was used as a positive control. Incubation with ISO for 3 hr resulted in a significant increase in the rates of lipolysis. However, there was no stimulation of lipolysis over the 3-hr incubation at any concentration or under any conditions for IGF-I or IGF-II. Furthermore, ST, PRL, or PL had no acute effects on the rates of lipolysis in adipose tissue. These data demonstrate that IGF-I, IGF-II, ST, PRL, and PL are not acute effectors of the lipolytic rate in the adipose tissue of ruminants.

Original languageEnglish (US)
Pages (from-to)239-249
Number of pages11
JournalDomestic Animal Endocrinology
Volume13
Issue number3
StatePublished - 1996
Externally publishedYes

Fingerprint

choriomammotropin
Placental Lactogen
Insulin-Like Growth Factor II
Lipolysis
Ruminants
lipolysis
insulin-like growth factor I
prolactin
Insulin-Like Growth Factor I
Prolactin
somatotropin
Growth Hormone
ruminants
insulin-like growth factor II
adipose tissue
Adipose Tissue
Isoproterenol
ewes
adrenergic agonists
Adrenergic Agonists

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology
  • veterinary(all)

Cite this

Insulin-like growth factors-I and -II, somatotropin, prolactin, and placental lactogen are not acute effectors of lipolysis in ruminants. / Houseknecht, K. L.; Bauman, D. E.; Vernon, R. G.; Byatt, J. C.; Collier, Robert J.

In: Domestic Animal Endocrinology, Vol. 13, No. 3, 1996, p. 239-249.

Research output: Contribution to journalArticle

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