Insulin-like Peptides: Structure, Signaling, and Function

Yevgeniya Antonova, Anam J. Arik, Wendy Moore Brusca, Michael A Riehle, Mark R. Brown

Research output: Chapter in Book/Report/Conference proceedingChapter

65 Citations (Scopus)

Abstract

This chapter discusses the insulin-like peptides: structure, signaling, and function. Insulin-like peptides (ILPs) are paragons for the conservation of hormone structure and function among invertebrates and higher animals. They are encoded by multiple, distinct genes within each species and, upon secretion, serve as hormones, neurotransmitters, and growth factors during post-embryonic life stages. These diverse messages are transduced in target cells through an insulin receptor and a signaling network of activated proteins that directly affect biochemical pathways and gene expression. Of the diverse invertebrate groups, our accumulated knowledge of ILP endocrinology is the deepest and broadest for insects. This knowledge has revealed that essentially all of the proteins that make up the mechanisms for ILP processing, secretion, and signaling are remarkably similar to those of vertebrates, in effect conserving the pleiotropic effects of ILPs between insects and vertebrates.

Original languageEnglish (US)
Title of host publicationInsect Endocrinology
PublisherElsevier
Pages63-92
Number of pages30
ISBN (Print)9780123847492
DOIs
StatePublished - 2012

Fingerprint

insulin
peptides
Insulin
Peptides
Invertebrates
Insects
Vertebrates
insulin-like effect
invertebrates
vertebrates
hormones
secretion
Hormones
insects
endocrinology
Endocrinology
Insulin Receptor
neurotransmitters
growth factors
Neurotransmitter Agents

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Antonova, Y., Arik, A. J., Moore Brusca, W., Riehle, M. A., & Brown, M. R. (2012). Insulin-like Peptides: Structure, Signaling, and Function. In Insect Endocrinology (pp. 63-92). Elsevier. https://doi.org/10.1016/B978-0-12-384749-2.10002-0

Insulin-like Peptides : Structure, Signaling, and Function. / Antonova, Yevgeniya; Arik, Anam J.; Moore Brusca, Wendy; Riehle, Michael A; Brown, Mark R.

Insect Endocrinology. Elsevier, 2012. p. 63-92.

Research output: Chapter in Book/Report/Conference proceedingChapter

Antonova, Yevgeniya ; Arik, Anam J. ; Moore Brusca, Wendy ; Riehle, Michael A ; Brown, Mark R. / Insulin-like Peptides : Structure, Signaling, and Function. Insect Endocrinology. Elsevier, 2012. pp. 63-92
@inbook{6fb4f62bc2804e328a4b6796420f416b,
title = "Insulin-like Peptides: Structure, Signaling, and Function",
abstract = "This chapter discusses the insulin-like peptides: structure, signaling, and function. Insulin-like peptides (ILPs) are paragons for the conservation of hormone structure and function among invertebrates and higher animals. They are encoded by multiple, distinct genes within each species and, upon secretion, serve as hormones, neurotransmitters, and growth factors during post-embryonic life stages. These diverse messages are transduced in target cells through an insulin receptor and a signaling network of activated proteins that directly affect biochemical pathways and gene expression. Of the diverse invertebrate groups, our accumulated knowledge of ILP endocrinology is the deepest and broadest for insects. This knowledge has revealed that essentially all of the proteins that make up the mechanisms for ILP processing, secretion, and signaling are remarkably similar to those of vertebrates, in effect conserving the pleiotropic effects of ILPs between insects and vertebrates.",
author = "Yevgeniya Antonova and Arik, {Anam J.} and {Moore Brusca}, Wendy and Riehle, {Michael A} and Brown, {Mark R.}",
year = "2012",
doi = "10.1016/B978-0-12-384749-2.10002-0",
language = "English (US)",
isbn = "9780123847492",
pages = "63--92",
booktitle = "Insect Endocrinology",
publisher = "Elsevier",

}

TY - CHAP

T1 - Insulin-like Peptides

T2 - Structure, Signaling, and Function

AU - Antonova, Yevgeniya

AU - Arik, Anam J.

AU - Moore Brusca, Wendy

AU - Riehle, Michael A

AU - Brown, Mark R.

PY - 2012

Y1 - 2012

N2 - This chapter discusses the insulin-like peptides: structure, signaling, and function. Insulin-like peptides (ILPs) are paragons for the conservation of hormone structure and function among invertebrates and higher animals. They are encoded by multiple, distinct genes within each species and, upon secretion, serve as hormones, neurotransmitters, and growth factors during post-embryonic life stages. These diverse messages are transduced in target cells through an insulin receptor and a signaling network of activated proteins that directly affect biochemical pathways and gene expression. Of the diverse invertebrate groups, our accumulated knowledge of ILP endocrinology is the deepest and broadest for insects. This knowledge has revealed that essentially all of the proteins that make up the mechanisms for ILP processing, secretion, and signaling are remarkably similar to those of vertebrates, in effect conserving the pleiotropic effects of ILPs between insects and vertebrates.

AB - This chapter discusses the insulin-like peptides: structure, signaling, and function. Insulin-like peptides (ILPs) are paragons for the conservation of hormone structure and function among invertebrates and higher animals. They are encoded by multiple, distinct genes within each species and, upon secretion, serve as hormones, neurotransmitters, and growth factors during post-embryonic life stages. These diverse messages are transduced in target cells through an insulin receptor and a signaling network of activated proteins that directly affect biochemical pathways and gene expression. Of the diverse invertebrate groups, our accumulated knowledge of ILP endocrinology is the deepest and broadest for insects. This knowledge has revealed that essentially all of the proteins that make up the mechanisms for ILP processing, secretion, and signaling are remarkably similar to those of vertebrates, in effect conserving the pleiotropic effects of ILPs between insects and vertebrates.

UR - http://www.scopus.com/inward/record.url?scp=84859363786&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859363786&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-384749-2.10002-0

DO - 10.1016/B978-0-12-384749-2.10002-0

M3 - Chapter

AN - SCOPUS:84859363786

SN - 9780123847492

SP - 63

EP - 92

BT - Insect Endocrinology

PB - Elsevier

ER -