Interaction between cisplatin and mesna in mice

Robert T. Dorr, Kristina Lagel

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The uroprotectant thiol mesna was found to protect adult CD-1 mice from high-dose cisplatin lethality. Mesna doses of 50 mg/kg were given with cisplatin, or 5 min after cisplatin (25 or 30 mg/kg) and acute survival was increased in non-tumor-bearing mice. In contrast, mesna mixed directly with cisplatin significantly reduced cisplatin antitumor effects in DBA/2J mice given 106 P-388 leukemia i.p. Mesna administered i.p. 5 min after cisplatin (6,8 or 10 mg/kg) did not reduce cisplatins' antitumor efficacy in this same tumor model. Mesna appears to inactivate cisplatin directly in vitro but possibly not in vivo if separate injections are used.

Original languageEnglish (US)
Pages (from-to)604-605
Number of pages2
JournalJournal of Cancer Research and Clinical Oncology
Volume115
Issue number6
DOIs
StatePublished - Nov 1 1989

Keywords

  • Cisplatin
  • Mesna
  • Mice

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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