Interaction of body mass index or waist-to-hip ratio and sun exposure associated with nonmelanoma skin cancer: A prospective study from the Women’s Health Initiative

Alfred A. Chan, Juliana Noguti, Youngju Pak, Lihong Qi, Bette Caan, Scott B Going, Jiali Han, Rowan T. Chlebowski, Delphine J. Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The incidence of nonmelanoma skin cancer (NMSC) exceeds the incidence of all other types of cancers combined. Cumulative sun exposure and intermittent sun exposure are known risk factors for the development of NMSC. Because obesity has been shown to decrease the risk of NMSC incidence, this study investigated whether the risk of NMSC with sun exposure was consistent across different levels of body size. Methods: Body size was assessed with the body mass index (BMI) and the waist-to-hip ratio (WHR). Sun exposure was assessed in watts and langleys and by the amount of time spent outdoors per day in the summer during a person’s 30s. Results: Among 71,645 postmenopausal women eligible for inclusion in this study, 13,351 participants (18.6%) developed NMSC. A BMI ≥ 25 kg/m2 or a WHR ≥ 0.80 was associated with lower NMSC hazard rates (hazard ratio for BMI, 0.78; hazard ratio for WHR, 0.89); however, the association between higher levels of sun exposure and a higher risk of NMSC was more apparent among women with a BMI ≥ 25 kg/m2 or a WHR ≥ 0.80 in comparison with those of a normal weight (P for interaction for BMI <.001; P for interaction for WHR =.022). Conclusions: Although most studies have considered sun exposure as a covariate, none have addressed the potential interaction of body size with sun exposure; therefore, the effect size of being overweight or obese may have been overestimated. In comparison to the normal-weight group, those in the overweight group had increasingly higher hazard rates with increasing sun exposure. Further studies are warranted to investigate how increased weight interacts with sun exposure to influence skin cancer pathogenesis.

Original languageEnglish (US)
JournalCancer
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Waist-Hip Ratio
Skin Neoplasms
Women's Health
Solar System
Body Mass Index
Prospective Studies
Body Size
Weights and Measures
Incidence
Cohort Studies
Obesity

Keywords

  • body mass index (BMI)
  • nonmelanoma skin cancer (NMSC)
  • obesity
  • overweight
  • postmenopausal women
  • skin cancer
  • sun exposure
  • ultraviolet
  • waist-to-hip ratio (WHR)
  • Women’s Health Initiative

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Interaction of body mass index or waist-to-hip ratio and sun exposure associated with nonmelanoma skin cancer : A prospective study from the Women’s Health Initiative. / Chan, Alfred A.; Noguti, Juliana; Pak, Youngju; Qi, Lihong; Caan, Bette; Going, Scott B; Han, Jiali; Chlebowski, Rowan T.; Lee, Delphine J.

In: Cancer, 01.01.2018.

Research output: Contribution to journalArticle

Chan, Alfred A. ; Noguti, Juliana ; Pak, Youngju ; Qi, Lihong ; Caan, Bette ; Going, Scott B ; Han, Jiali ; Chlebowski, Rowan T. ; Lee, Delphine J. / Interaction of body mass index or waist-to-hip ratio and sun exposure associated with nonmelanoma skin cancer : A prospective study from the Women’s Health Initiative. In: Cancer. 2018.
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title = "Interaction of body mass index or waist-to-hip ratio and sun exposure associated with nonmelanoma skin cancer: A prospective study from the Women’s Health Initiative",
abstract = "Background: The incidence of nonmelanoma skin cancer (NMSC) exceeds the incidence of all other types of cancers combined. Cumulative sun exposure and intermittent sun exposure are known risk factors for the development of NMSC. Because obesity has been shown to decrease the risk of NMSC incidence, this study investigated whether the risk of NMSC with sun exposure was consistent across different levels of body size. Methods: Body size was assessed with the body mass index (BMI) and the waist-to-hip ratio (WHR). Sun exposure was assessed in watts and langleys and by the amount of time spent outdoors per day in the summer during a person’s 30s. Results: Among 71,645 postmenopausal women eligible for inclusion in this study, 13,351 participants (18.6{\%}) developed NMSC. A BMI ≥ 25 kg/m2 or a WHR ≥ 0.80 was associated with lower NMSC hazard rates (hazard ratio for BMI, 0.78; hazard ratio for WHR, 0.89); however, the association between higher levels of sun exposure and a higher risk of NMSC was more apparent among women with a BMI ≥ 25 kg/m2 or a WHR ≥ 0.80 in comparison with those of a normal weight (P for interaction for BMI <.001; P for interaction for WHR =.022). Conclusions: Although most studies have considered sun exposure as a covariate, none have addressed the potential interaction of body size with sun exposure; therefore, the effect size of being overweight or obese may have been overestimated. In comparison to the normal-weight group, those in the overweight group had increasingly higher hazard rates with increasing sun exposure. Further studies are warranted to investigate how increased weight interacts with sun exposure to influence skin cancer pathogenesis.",
keywords = "body mass index (BMI), nonmelanoma skin cancer (NMSC), obesity, overweight, postmenopausal women, skin cancer, sun exposure, ultraviolet, waist-to-hip ratio (WHR), Women’s Health Initiative",
author = "Chan, {Alfred A.} and Juliana Noguti and Youngju Pak and Lihong Qi and Bette Caan and Going, {Scott B} and Jiali Han and Chlebowski, {Rowan T.} and Lee, {Delphine J.}",
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T1 - Interaction of body mass index or waist-to-hip ratio and sun exposure associated with nonmelanoma skin cancer

T2 - A prospective study from the Women’s Health Initiative

AU - Chan, Alfred A.

AU - Noguti, Juliana

AU - Pak, Youngju

AU - Qi, Lihong

AU - Caan, Bette

AU - Going, Scott B

AU - Han, Jiali

AU - Chlebowski, Rowan T.

AU - Lee, Delphine J.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: The incidence of nonmelanoma skin cancer (NMSC) exceeds the incidence of all other types of cancers combined. Cumulative sun exposure and intermittent sun exposure are known risk factors for the development of NMSC. Because obesity has been shown to decrease the risk of NMSC incidence, this study investigated whether the risk of NMSC with sun exposure was consistent across different levels of body size. Methods: Body size was assessed with the body mass index (BMI) and the waist-to-hip ratio (WHR). Sun exposure was assessed in watts and langleys and by the amount of time spent outdoors per day in the summer during a person’s 30s. Results: Among 71,645 postmenopausal women eligible for inclusion in this study, 13,351 participants (18.6%) developed NMSC. A BMI ≥ 25 kg/m2 or a WHR ≥ 0.80 was associated with lower NMSC hazard rates (hazard ratio for BMI, 0.78; hazard ratio for WHR, 0.89); however, the association between higher levels of sun exposure and a higher risk of NMSC was more apparent among women with a BMI ≥ 25 kg/m2 or a WHR ≥ 0.80 in comparison with those of a normal weight (P for interaction for BMI <.001; P for interaction for WHR =.022). Conclusions: Although most studies have considered sun exposure as a covariate, none have addressed the potential interaction of body size with sun exposure; therefore, the effect size of being overweight or obese may have been overestimated. In comparison to the normal-weight group, those in the overweight group had increasingly higher hazard rates with increasing sun exposure. Further studies are warranted to investigate how increased weight interacts with sun exposure to influence skin cancer pathogenesis.

AB - Background: The incidence of nonmelanoma skin cancer (NMSC) exceeds the incidence of all other types of cancers combined. Cumulative sun exposure and intermittent sun exposure are known risk factors for the development of NMSC. Because obesity has been shown to decrease the risk of NMSC incidence, this study investigated whether the risk of NMSC with sun exposure was consistent across different levels of body size. Methods: Body size was assessed with the body mass index (BMI) and the waist-to-hip ratio (WHR). Sun exposure was assessed in watts and langleys and by the amount of time spent outdoors per day in the summer during a person’s 30s. Results: Among 71,645 postmenopausal women eligible for inclusion in this study, 13,351 participants (18.6%) developed NMSC. A BMI ≥ 25 kg/m2 or a WHR ≥ 0.80 was associated with lower NMSC hazard rates (hazard ratio for BMI, 0.78; hazard ratio for WHR, 0.89); however, the association between higher levels of sun exposure and a higher risk of NMSC was more apparent among women with a BMI ≥ 25 kg/m2 or a WHR ≥ 0.80 in comparison with those of a normal weight (P for interaction for BMI <.001; P for interaction for WHR =.022). Conclusions: Although most studies have considered sun exposure as a covariate, none have addressed the potential interaction of body size with sun exposure; therefore, the effect size of being overweight or obese may have been overestimated. In comparison to the normal-weight group, those in the overweight group had increasingly higher hazard rates with increasing sun exposure. Further studies are warranted to investigate how increased weight interacts with sun exposure to influence skin cancer pathogenesis.

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KW - ultraviolet

KW - waist-to-hip ratio (WHR)

KW - Women’s Health Initiative

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