Interaction of pathogenic neisseriae with nonphagocytic cells

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The ability to interact with nonphagocytic cells is a crucial virulence attribute of the meningococcus and the genococcus. Like most bacterial pathogens, Neisseria meningitidis and Neisseria gonorrhoeae initiate infections by colonizing the mucosal epithelium, which serves as the site of entry. After this step, both bacteria cross the intact mucosal barrier. While N. gonorrhoeae is likely to remain in the subepithelial matrix where it initiates an intense inflammatory reaction, N. meningitidis enters the bloodstream and eventually the cerebrospinal fluid to cause meningitis. Both pathogens have evolved very similar mechanisms for interacting with host cells. Surface structures that influence bacterium-host interactions include pili, the meningococcal class 5 outer membrane proteins or the gonococcal opacity proteins, lipooligosaccharide, and the meningococcal capsule. This review examines what is known about the roles these structures play in bacterial adhesion and invasion, with special emphasis on pilus-mediated adhesion. Finally the importance of these structures in neisserial pathogenesis is discussed.

Original languageEnglish (US)
Pages (from-to)376-388
Number of pages13
JournalClinical Microbiology Reviews
Volume8
Issue number3
StatePublished - 1995
Externally publishedYes

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Neisseria
Neisseria meningitidis
Neisseria gonorrhoeae
Bacterial Adhesion
Bacteria
Meningitis
Capsules
Virulence
Cerebrospinal Fluid
Membrane Proteins
Epithelium
Infection

ASJC Scopus subject areas

  • Microbiology

Cite this

Interaction of pathogenic neisseriae with nonphagocytic cells. / Nassif, X.; So, Magdalene "Maggie".

In: Clinical Microbiology Reviews, Vol. 8, No. 3, 1995, p. 376-388.

Research output: Contribution to journalArticle

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