Interactions and developmental effects of mutations in the Broad-Complex of Drosophila melanogaster.

I. Kiss, A. H. Beaton, Jil C Tardiff, D. Fristrom, J. W. Fristrom

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

The 2B5 region on the X chromosome of Drosophila melanogaster forms an early ecdysone puff at the end of the third larval instar. The region contains a complex genetic locus, the Broad-Complex (BR-C) composed of four groups of fully complementing (br, rbp, l(1)2Bc, and l(1)2Bd) alleles, and classes of noncomplementing (npr 1) and partially noncomplementing l(1)2Bab alleles. BR-C mutants prevent metamorphosis, including the morphogenesis of imaginal discs. Results are presented that indicate that the BR-C contains two major functional domains. One, the br domain is primarily, if not exclusively, involved in the elongation and eversion of appendages by imaginal discs. The second, the l(1)2Bc domain, is primarily involved in the fusion of discs to form a continuous adult epidermis. Nonetheless, the two domains may encode products with related functions because in some situations mutants in both domains appear to affect similar developmental processes.

Original languageEnglish (US)
Pages (from-to)247-259
Number of pages13
JournalGenetics
Volume118
Issue number2
StatePublished - Feb 1988
Externally publishedYes

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Imaginal Discs
Drosophila melanogaster
Alleles
Ecdysone
Mutation
Genetic Loci
X Chromosome
Morphogenesis
Epidermis

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Kiss, I., Beaton, A. H., Tardiff, J. C., Fristrom, D., & Fristrom, J. W. (1988). Interactions and developmental effects of mutations in the Broad-Complex of Drosophila melanogaster. Genetics, 118(2), 247-259.

Interactions and developmental effects of mutations in the Broad-Complex of Drosophila melanogaster. / Kiss, I.; Beaton, A. H.; Tardiff, Jil C; Fristrom, D.; Fristrom, J. W.

In: Genetics, Vol. 118, No. 2, 02.1988, p. 247-259.

Research output: Contribution to journalArticle

Kiss, I, Beaton, AH, Tardiff, JC, Fristrom, D & Fristrom, JW 1988, 'Interactions and developmental effects of mutations in the Broad-Complex of Drosophila melanogaster.', Genetics, vol. 118, no. 2, pp. 247-259.
Kiss, I. ; Beaton, A. H. ; Tardiff, Jil C ; Fristrom, D. ; Fristrom, J. W. / Interactions and developmental effects of mutations in the Broad-Complex of Drosophila melanogaster. In: Genetics. 1988 ; Vol. 118, No. 2. pp. 247-259.
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