Interferometric detection of early markers for epithelial ovarian cancer and prognostic markers for acute lymphocytic leukemia

P. O'Neil, Ming Zhao, X. Wang, D. D. Nolte

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We are developing fluorescence-free interferometric biosensors for the early detection of epithelial ovarian cancer (EOC) and prognosis of acute lymphocytic leukemia (ALL). We can detect potential early markers for EOC (CA125, human epididymus protein 4, osteopontin) spiked into serum as well as elevated CA125 in EOC patient serum. For ALL prognosis we are focusing on three intracellular protein markers (p73, p57/Kip2, and p15/Ink4b), the down-regulation of any two being indicative of a more aggressive cancer. We have detected p15 and p57 spiked into buffer and are preparing to test positive and negative control lysates from bone marrow biopsies.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7555
DOIs
Publication statusPublished - 2010
Externally publishedYes
EventAdvanced Biomedical and Clinical Diagnostic Systems VIII - San Francisco, CA, United States
Duration: Jan 24 2010Jan 26 2010

Other

OtherAdvanced Biomedical and Clinical Diagnostic Systems VIII
CountryUnited States
CitySan Francisco, CA
Period1/24/101/26/10

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Keywords

  • Biointerferometry
  • Cancer biomarkers
  • Molecular interferometric imaging
  • Optical biosensors

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

O'Neil, P., Zhao, M., Wang, X., & Nolte, D. D. (2010). Interferometric detection of early markers for epithelial ovarian cancer and prognostic markers for acute lymphocytic leukemia. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7555). [75551Q] https://doi.org/10.1117/12.841859