Interleukin-13

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Few genes appear to be as critical for the pathogenesis of allergic inflammation in humans and animal models as interleukin (IL)-13, and even fewer appear to determine susceptibility to allergy and Asthma across human populations as consistently as IL-13. The reason behind the central role of this cytokine in disease pathogenesis probably lies in the properties of IL-13, the frequency with which the human IL-13 locus is targeted by natural genetic variation, and the functional consequences of this variation. Here we will discuss the properties of IL-13 relevant to allergic lung inflammation; we will review the results of genetic association studies investigating the relationship between IL-13 polymorphisms and allergic phenotypes; and we will propose a blueprint for functional studies of genetic variation based on the experience gained through the analysis of a common IL-13 coding variant.

Original languageEnglish (US)
Title of host publicationGenetics of Asthma and Chronic Obstructive Pulmonary Disease
PublisherCRC Press
Pages317-332
Number of pages16
ISBN (Electronic)9781420019728
ISBN (Print)9780849369667
StatePublished - Jan 1 2006

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Interleukin-13
Allergies
Blueprints
Genetic Association Studies
Polymorphism
Pneumonia
Hypersensitivity
Animals
Asthma
Animal Models
Genes
Cytokines
Inflammation
Phenotype
Population

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Vercelli, D. (2006). Interleukin-13. In Genetics of Asthma and Chronic Obstructive Pulmonary Disease (pp. 317-332). CRC Press.

Interleukin-13. / Vercelli, Donata.

Genetics of Asthma and Chronic Obstructive Pulmonary Disease. CRC Press, 2006. p. 317-332.

Research output: Chapter in Book/Report/Conference proceedingChapter

Vercelli, D 2006, Interleukin-13. in Genetics of Asthma and Chronic Obstructive Pulmonary Disease. CRC Press, pp. 317-332.
Vercelli D. Interleukin-13. In Genetics of Asthma and Chronic Obstructive Pulmonary Disease. CRC Press. 2006. p. 317-332
Vercelli, Donata. / Interleukin-13. Genetics of Asthma and Chronic Obstructive Pulmonary Disease. CRC Press, 2006. pp. 317-332
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