Interleukin-13 regulates the phenotype and function of human monocytes

G. Viale, D. Vercelli

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The monocyte glycosylphosphatidylinositol (GPI)-linked protein CD14 serves as the receptor for lipopolysaccharide (LPS), and regulates monocyte-lymphocyte interactions. We investigated whether CD14 expression is regulated by interleukin (IL)-13, a member of the chromosome 5 cytokine family. IL-13 inhibited CD14 expression on human monocytes. CD14 down-regulation resulted in the inhibition of LPS-induced release of tumor necrosis factor α, and involved neither shedding nor activation of endogenous GPI-anchor cleaving enzymes. The CD14/actin RNA ratio was decreased 7-fold in IL-13-treated monocytes. Our results suggest that IL-13 down-regulates CD14 by suppressing CD14 RNA expression. Down-regulation of CD14, the LPS receptor, may play a major role in the anti-inflammatory effects of IL-13.

Original languageEnglish (US)
Pages (from-to)176-178
Number of pages3
JournalInternational Archives of Allergy and Immunology
Volume107
Issue number1-3
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Keywords

  • CD14
  • Interleukin-13
  • Monocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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