Interleukin-36γIs Elevated in Cervicovaginal Epithelial Cells in Women with Bacterial Vaginosis and in Vitro after Infection with Microbes Associated with Bacterial Vaginosis

Jameson K. Gardner, Paweł Łaniewski, Anna Knight, Lisa B. Haddad, Alison Swaims-Kohlmeier, Melissa M. Herbst-Kralovetz

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In recent studies, the interleukin (IL)-36 cytokines were shown to be elevated in women with non-Lactobacillus-dominated vaginal microbiomes. In this study, we evaluated IL36G expression in clinical samples from women with and without bacterial vaginosis (BV) and a human 3-dimensional cervical epithelial cell model. IL36G expression was significantly elevated in cervicovaginal epithelial cells isolated from BV-positive women and corresponded with increased neutrophil counts relative to BV-negative women. In addition, specific BV-associated bacterial species as well as a polymicrobial cocktail significantly induced IL36G expression in vitro. These findings suggest that IL-36γmay exhibit an important function in the host response to BV and other sexually transmitted infections.

Original languageEnglish (US)
Pages (from-to)983-988
Number of pages6
JournalJournal of Infectious Diseases
Volume221
Issue number6
DOIs
StatePublished - Mar 15 2020

Keywords

  • Atopobium vaginae
  • Gardnerella vaginalis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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