Interleukin 4 dependent induction of IGE synthesis and CD23 expression by the supernatants of a human helper T cell clone

Donata Vercelli, Donald Y.M. Leung, Haifa H. Jabara, Raif S. Geha

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The supernatants of the human alloreactive helper T cell clone Al, which secretes interleukins (IL) 4 and 5, could induce IgE synthesis by normal peripheral blood mononuclear cells and expression of FceR2/CD23 on normal human monocytes. Both effects were IL-4 dependent, since they could be induced by recombinant IL-4 alone and were inhibited by an anti-lL-4 antibody. The activation of such clones may contribute to the high IgE production and the high percentage of circulating CD23+ monocytes observed in allergic disorders.

Original languageEnglish (US)
Pages (from-to)119-121
Number of pages3
JournalInternational Archives of Allergy and Immunology
Volume88
Issue number1-2
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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