Interleukin 4 dependent induction of IgE synthesis and CD23 expression by the supernatants of a human helper T cell clone

Donata Vercelli, D. Y M Leung, H. H. Jabara, R. S. Geha

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The supernatants of the human alloreactive helper T cell clone A1, which secretes interleukins (IL) 4 and 5, could induce IgE synthesis by normal peripheral blood mononuclear cells and expression of FcεR2/CD23 on normal human monocytes. Both effects were IL-4 dependent, since they could be induced by recombinant IL-4 alone and were inhibited by an anti-IL-4 antibody. The activation of such clones may contribute to the high IgE production and the high percentage of circulating CD23+ monocytes observed in allergic disorders.

Original languageEnglish (US)
Pages (from-to)119-121
Number of pages3
JournalInternational Archives of Allergy and Applied Immunology
Volume88
Issue number1-2
StatePublished - 1989
Externally publishedYes

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Helper-Inducer T-Lymphocytes
Interleukin-4
Immunoglobulin E
Clone Cells
Monocytes
Interleukin-5
Blood Cells
Antibodies

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Interleukin 4 dependent induction of IgE synthesis and CD23 expression by the supernatants of a human helper T cell clone. / Vercelli, Donata; Leung, D. Y M; Jabara, H. H.; Geha, R. S.

In: International Archives of Allergy and Applied Immunology, Vol. 88, No. 1-2, 1989, p. 119-121.

Research output: Contribution to journalArticle

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