Intermediate filaments. Efficacy in surgical pathologic diagnosis

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The use of antibodies specific for the various types of intermediate filament proteins has become an important part of the immunohistochemical approach to surgical pathology. These proteins are expressed in a cell lineage-specific pattern, which is reproduced with great fidelity even in poorly differentiated neoplasms. The historic discovery, embryology, and structure of these proteins are reviewed. A brief discussion of the major applications and precautions in the choice and use of these antibodies is presented.

Original languageEnglish (US)
JournalAmerican Journal of Clinical Pathology
Volume91
Issue number4 SUPPL. 1
StatePublished - 1989

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Intermediate Filaments
Intermediate Filament Proteins
Surgical Pathology
Embryology
Antibodies
Cell Lineage
Proteins
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Intermediate filaments. Efficacy in surgical pathologic diagnosis. / Nagle, Raymond B.

In: American Journal of Clinical Pathology, Vol. 91, No. 4 SUPPL. 1, 1989.

Research output: Contribution to journalArticle

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