The use of antibodies specific for the various types of intermediate filament proteins has become an important part of the immunohistochemical approach to surgical pathology. These proteins are expressed in a cell lineage-specific pattern, which is reproduced with great fidelity even in poorly differentiated neoplasms. The historic discovery, embryology, and structure of these proteins are reviewed. A brief discussion of the major applications and precautions in the choice and use of these antibodies is presented.
|Original language||English (US)|
|Journal||American journal of clinical pathology|
|Issue number||4 SUPPL. 1|
|State||Published - Jan 1 1989|
ASJC Scopus subject areas
- Pathology and Forensic Medicine