Interrelationships of quantitative asthma-related phenotypes in the Epidemiological Study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy

Marie Pierre Oryszczyn, Emmanuelle Bouzigon, Jean Maccario, Valérie Siroux, Rachel Nadif, Anne L Wright, Francine Kauffmann

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Delineating asthma subphenotypes is of interest to understand the cause of the disease. Few studies have addressed the interrelationships of quantitative asthma-related traits. Objective: We sought to study the interrelationships of allergy markers and FEV1 in relation to asthma and sex in children and adults. Methods: Total IgE levels, skin prick test (SPT) positivity, eosinophil counts, and FEV1 were assessed in 299 asthmatic cases (children and adults) recruited in chest clinics and 309 nonasthmatic population-based control subjects in the French Epidemiological Study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy. Results: Allergy parameters were significantly higher in asthmatic cases than in control subjects for children and adults and for both sexes. Sex and age modified the pattern of concordance of high IgE levels, SPT positivity, and eosinophilia among asthmatic cases, with the greatest overlap in male children (64%) and the lowest in male adults (18%). Patterns of change over the lifespan of IgE levels, eosinophil counts, and FEV1/height2 varied, with the acceleration of FEV1 decrease being particularly evident in asthmatic adults. In adult cases and control subjects, SPT positivity (particularly to indoor allergens) was significantly related to IgE levels but not to eosinophil counts. The association of eosinophil counts with IgE levels was evident only in children. Environmental factors (smoking, pets, and country living) did not alter the patterns observed. Conclusions: Each allergy-related phenotype showed a distinct relation with asthma, with the role for eosinophils being different than that for IgE levels and SPT responses. Clinical implications: Taking age and sex into account is essential for understanding the interrelationships of the various allergy-related phenotypes to asthma status.

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Volume119
Issue number1
DOIs
StatePublished - Jan 2007

Fingerprint

Immunoglobulin E
Epidemiologic Studies
Eosinophils
Asthma
Skin Tests
Phenotype
Hypersensitivity
Population Control
Pets
Eosinophilia
Allergens
Thorax
Smoking

Keywords

  • Allergy
  • asthma
  • eosinophils
  • epidemiology
  • IgE
  • lung function
  • sex

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Interrelationships of quantitative asthma-related phenotypes in the Epidemiological Study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy. / Oryszczyn, Marie Pierre; Bouzigon, Emmanuelle; Maccario, Jean; Siroux, Valérie; Nadif, Rachel; Wright, Anne L; Kauffmann, Francine.

In: Journal of Allergy and Clinical Immunology, Vol. 119, No. 1, 01.2007, p. 57-63.

Research output: Contribution to journalArticle

Oryszczyn, Marie Pierre ; Bouzigon, Emmanuelle ; Maccario, Jean ; Siroux, Valérie ; Nadif, Rachel ; Wright, Anne L ; Kauffmann, Francine. / Interrelationships of quantitative asthma-related phenotypes in the Epidemiological Study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy. In: Journal of Allergy and Clinical Immunology. 2007 ; Vol. 119, No. 1. pp. 57-63.
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AB - Background: Delineating asthma subphenotypes is of interest to understand the cause of the disease. Few studies have addressed the interrelationships of quantitative asthma-related traits. Objective: We sought to study the interrelationships of allergy markers and FEV1 in relation to asthma and sex in children and adults. Methods: Total IgE levels, skin prick test (SPT) positivity, eosinophil counts, and FEV1 were assessed in 299 asthmatic cases (children and adults) recruited in chest clinics and 309 nonasthmatic population-based control subjects in the French Epidemiological Study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy. Results: Allergy parameters were significantly higher in asthmatic cases than in control subjects for children and adults and for both sexes. Sex and age modified the pattern of concordance of high IgE levels, SPT positivity, and eosinophilia among asthmatic cases, with the greatest overlap in male children (64%) and the lowest in male adults (18%). Patterns of change over the lifespan of IgE levels, eosinophil counts, and FEV1/height2 varied, with the acceleration of FEV1 decrease being particularly evident in asthmatic adults. In adult cases and control subjects, SPT positivity (particularly to indoor allergens) was significantly related to IgE levels but not to eosinophil counts. The association of eosinophil counts with IgE levels was evident only in children. Environmental factors (smoking, pets, and country living) did not alter the patterns observed. Conclusions: Each allergy-related phenotype showed a distinct relation with asthma, with the role for eosinophils being different than that for IgE levels and SPT responses. Clinical implications: Taking age and sex into account is essential for understanding the interrelationships of the various allergy-related phenotypes to asthma status.

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